The peripheral nervous system can be vulnerable to the toxic action of several drugs since it
is not protected as effectively as the central nervous system from noxious exogenous agents …

CONTEXT: New data regarding treatment of muscle-invasive and metastatic bladder cancer
(MiM-BC) has emerged and led to an update of the European Association of Urology (EAU) …

There have been no major advances for the treatment of metastatic urothelial bladder
cancer (UBC) in the last 30 years. Chemotherapy is still the standard of care. Patient …

Context Invasive bladder cancer is a frequently occurring disease with a high mortality rate
despite optimal treatment. The European Association of Urology (EAU) Muscle-invasive and …

Purpose Vinflunine (VFL) is a new microtubule inhibitor that has activity against transitional
cell carcinoma of urothelial tract (TCCU). We conducted a randomized phase III study of VFL …

Microtubules are important cellular targets for anticancer therapy because of their key role in
mitosis. Microtubule inhibitors (MTI) such as taxanes, vinca alkaloids, and epothilones …

Purpose The present study sought to identify pretreatment prognostic factors for overall
survival (OS) in patients with metastatic transitional cell carcinoma of the urothelial tract …

Increasing recurrence of mammalian tumors and severe side-effects of chemotherapeutic
agents reduce the clinical efficacy of a large variety of anticancer agents that are currently …

BACKGROUND: The treatment of recurrent transitional cell carcinoma (TCC) remains an
unmet clinical need. This study assessed lapatinib, a dual tyrosine kinase inhibitor of …

Purpose We comprehensively reviewed current efforts and advances in the field of
chemotherapeutic and biologically targeted treatment options after the failure of cisplatin …