Targeted covalent inhibitors (TCIs) are designed to bind poorly conserved amino acids by
means of reactive groups, the so-called warheads. Currently, targeting noncatalytic cysteine …

Perineuronal nets (PNNs) in the brain are condensed glycosaminoglycan-rich extracellular
matrix structures with heterogeneous composition yet specific organization. They typically …

HS3ST1 is a genetic risk gene associated with Alzheimer's disease (AD) and overexpressed
in patients, but how it contributes to the disease progression is unknown. We report the …

Glycan alterations are associated with aging, neuropsychiatric, and neurodegenerative
diseases, although the contributions of specific glycan structures to emotion and cognitive …

A new series of pyridine-2-one and pyrazole derivatives were designed and synthesized
based on cyanoacrylamide derivatives containing 2, 4-dichlro aniline and 6-methyl 2-amino …

Cellular carbohydrates or glycans are critical mediators of biological function. Their
remarkably diverse structures and varied activities present exciting opportunities for …

The glycocalyx surrounds every eukaryotic cell and is a complex mesh of proteins and
carbohydrates. It consists of proteoglycans with glycosaminoglycan side chains, which are …

Chondroitin sulfate (CCS) was purified from discarded codfish (Gadus macrocephalus)
bones, and its chemical structure and anticoagulant activity were assessed. CCS was …

Glycans are one of the fundamental biopolymers encountered in living systems. Compared
to polynucleotide and polypeptide biosynthesis, polysaccharide biosynthesis is a uniquely …

Chondroitin sulfate (CS) is one of the major and widespread glycosaminoglycans, a family of
structurally complex, linear, anionic hetero-co-polysaccharides. CS plays a vital role in …