Clinical biomarkers in drug discovery and development

R Frank, R Hargreaves - Nature reviews Drug discovery, 2003 - nature.com
Biomarkers enable the characterization of patient populations and quantitation of the extent
to which new drugs reach intended targets, alter proposed pathophysiological mechanisms …

Prevalence and prognosis of nonobstructive coronary artery disease in patients undergoing coronary angiography or coronary computed tomography angiography: a …

ZJ Wang, LL Zhang, S Elmariah, HY Han… - Mayo Clinic …, 2017 - Elsevier
Objective To evaluate the prevalence, clinical characteristics, and risk of cardiac events in
patients with nonobstructive coronary artery disease (CAD). Patients and Methods We …

Effect of recombinant ApoA-I Milano on coronary atherosclerosis in patients with acute coronary syndromes: a randomized controlled trial

SE Nissen, T Tsunoda, EM Tuzcu, P Schoenhagen… - Jama, 2003 - jamanetwork.com
Context Although low levels of high-density lipoprotein cholesterol (HDL-C) increase risk for
coronary disease, no data exist regarding potential benefits of administration of HDL-C or an …

Quantification of obstructive and nonobstructive coronary lesions by 64-slice computed tomography: a comparative study with quantitative coronary angiography and …

AW Leber, A Knez, F von Ziegler, A Becker… - Journal of the American …, 2005 - jacc.org
Objectives: The aim of the present study was to determine the diagnostic accuracy of 64-
slice computed tomography (CT) to identify and quantify atherosclerotic coronary lesions in …

Role of noninvasive testing in the clinical evaluation of women with suspected ischemic heart disease: a consensus statement from the American Heart Association

JH Mieres, M Gulati, N Bairey Merz, DS Berman… - Circulation, 2014 - Am Heart Assoc
Historically, the focus of the diagnostic evaluation for symptomatic women and men has
been the detection of an obstructive coronary stenosis requiring revascularization (as …

Assessment of coronary remodeling in stenotic and nonstenotic coronary atherosclerotic lesions by multidetector spiral computed tomography

S Achenbach, D Ropers, U Hoffmann… - Journal of the American …, 2004 - jacc.org
Objectives: This study was designed to investigate whether contrast-enhanced multidetector
spiral CT (MDCT) permits assessment of remodeling in coronary atherosclerotic lesions …

Intravascular photoacoustic imaging of human coronary atherosclerosis

K Jansen, AFW Van Der Steen, HMM van Beusekom… - Optics letters, 2011 - opg.optica.org
We demonstrate intravascular photoacoustic imaging of human coronary atherosclerotic
plaque. The data was obtained from two fresh human coronary arteries ex vivo, showing …

A first-in-man, randomized, placebo-controlled study to evaluate the safety and feasibility of autologous delipidated high-density lipoprotein plasma infusions in …

R Waksman, R Torguson, KM Kent, AD Pichard… - Journal of the American …, 2010 - jacc.org
Objectives: This study aimed to determine whether serial autologous infusions of selective
high-density lipoprotein (HDL) delipidated plasma are feasible and well tolerated in patients …

Gender differences in coronary artery diameter are not related to body habitus or left ventricular mass

AK Hiteshi, D Li, Y Gao, A Chen, F Flores… - Clinical …, 2014 - Wiley Online Library
Background Smaller coronary artery diameter portends worse outcomes after coronary
artery bypass grafting (CABG) and percutaneous coronary intervention (PCI). The …

Regression of coronary atherosclerosis by simvastatin: a serial intravascular ultrasound study

LO Jensen, P Thayssen, KE Pedersen, S Stender… - Circulation, 2004 - Am Heart Assoc
Background—Angiography of the coronary arteries reflects only changes in luminal
dimensions. With intravascular ultrasound, cross-sectional images can be obtained and …