Clinical biomarkers in drug discovery and development
R Frank, R Hargreaves - Nature reviews Drug discovery, 2003 - nature.com
Biomarkers enable the characterization of patient populations and quantitation of the extent
to which new drugs reach intended targets, alter proposed pathophysiological mechanisms …
to which new drugs reach intended targets, alter proposed pathophysiological mechanisms …
Prevalence and prognosis of nonobstructive coronary artery disease in patients undergoing coronary angiography or coronary computed tomography angiography: a …
ZJ Wang, LL Zhang, S Elmariah, HY Han… - Mayo Clinic …, 2017 - Elsevier
Objective To evaluate the prevalence, clinical characteristics, and risk of cardiac events in
patients with nonobstructive coronary artery disease (CAD). Patients and Methods We …
patients with nonobstructive coronary artery disease (CAD). Patients and Methods We …
Effect of recombinant ApoA-I Milano on coronary atherosclerosis in patients with acute coronary syndromes: a randomized controlled trial
SE Nissen, T Tsunoda, EM Tuzcu, P Schoenhagen… - Jama, 2003 - jamanetwork.com
Context Although low levels of high-density lipoprotein cholesterol (HDL-C) increase risk for
coronary disease, no data exist regarding potential benefits of administration of HDL-C or an …
coronary disease, no data exist regarding potential benefits of administration of HDL-C or an …
Quantification of obstructive and nonobstructive coronary lesions by 64-slice computed tomography: a comparative study with quantitative coronary angiography and …
AW Leber, A Knez, F von Ziegler, A Becker… - Journal of the American …, 2005 - jacc.org
Objectives: The aim of the present study was to determine the diagnostic accuracy of 64-
slice computed tomography (CT) to identify and quantify atherosclerotic coronary lesions in …
slice computed tomography (CT) to identify and quantify atherosclerotic coronary lesions in …
Role of noninvasive testing in the clinical evaluation of women with suspected ischemic heart disease: a consensus statement from the American Heart Association
JH Mieres, M Gulati, N Bairey Merz, DS Berman… - Circulation, 2014 - Am Heart Assoc
Historically, the focus of the diagnostic evaluation for symptomatic women and men has
been the detection of an obstructive coronary stenosis requiring revascularization (as …
been the detection of an obstructive coronary stenosis requiring revascularization (as …
Assessment of coronary remodeling in stenotic and nonstenotic coronary atherosclerotic lesions by multidetector spiral computed tomography
S Achenbach, D Ropers, U Hoffmann… - Journal of the American …, 2004 - jacc.org
Objectives: This study was designed to investigate whether contrast-enhanced multidetector
spiral CT (MDCT) permits assessment of remodeling in coronary atherosclerotic lesions …
spiral CT (MDCT) permits assessment of remodeling in coronary atherosclerotic lesions …
Intravascular photoacoustic imaging of human coronary atherosclerosis
We demonstrate intravascular photoacoustic imaging of human coronary atherosclerotic
plaque. The data was obtained from two fresh human coronary arteries ex vivo, showing …
plaque. The data was obtained from two fresh human coronary arteries ex vivo, showing …
A first-in-man, randomized, placebo-controlled study to evaluate the safety and feasibility of autologous delipidated high-density lipoprotein plasma infusions in …
R Waksman, R Torguson, KM Kent, AD Pichard… - Journal of the American …, 2010 - jacc.org
Objectives: This study aimed to determine whether serial autologous infusions of selective
high-density lipoprotein (HDL) delipidated plasma are feasible and well tolerated in patients …
high-density lipoprotein (HDL) delipidated plasma are feasible and well tolerated in patients …
Gender differences in coronary artery diameter are not related to body habitus or left ventricular mass
Background Smaller coronary artery diameter portends worse outcomes after coronary
artery bypass grafting (CABG) and percutaneous coronary intervention (PCI). The …
artery bypass grafting (CABG) and percutaneous coronary intervention (PCI). The …
Regression of coronary atherosclerosis by simvastatin: a serial intravascular ultrasound study
LO Jensen, P Thayssen, KE Pedersen, S Stender… - Circulation, 2004 - Am Heart Assoc
Background—Angiography of the coronary arteries reflects only changes in luminal
dimensions. With intravascular ultrasound, cross-sectional images can be obtained and …
dimensions. With intravascular ultrasound, cross-sectional images can be obtained and …