[HTML][HTML] Role of androgen receptor in prostate cancer: a review
K Fujita, N Nonomura - The world journal of men's health, 2019 - ncbi.nlm.nih.gov
Androgen receptor (AR) is a steroid receptor transcriptional factor for testosterone and
dihydrotestosterone consisting of four main domains, the N-terminal domain, DNA-binding …
dihydrotestosterone consisting of four main domains, the N-terminal domain, DNA-binding …
Update on systemic prostate cancer therapies: management of metastatic castration-resistant prostate cancer in the era of precision oncology
P Nuhn, JS De Bono, K Fizazi, SJ Freedland, M Grilli… - European urology, 2019 - Elsevier
Context Introduction of novel agents for the management of advanced prostate cancer
provides a range of treatment options with notable benefits for men with metastatic castration …
provides a range of treatment options with notable benefits for men with metastatic castration …
[HTML][HTML] Prospective multicenter validation of androgen receptor splice variant 7 and hormone therapy resistance in high-risk castration-resistant prostate cancer: the …
PURPOSE Androgen receptor splice variant 7 (AR-V7) results in a truncated receptor, which
leads to ligand-independent constitutive activation that is not inhibited by anti-androgen …
leads to ligand-independent constitutive activation that is not inhibited by anti-androgen …
How to turn up the heat on the cold immune microenvironment of metastatic prostate cancer
Background Advanced prostate cancer remains one of the most common and deadly
cancers, despite advances in treatment options. Immunotherapy has provided little benefit to …
cancers, despite advances in treatment options. Immunotherapy has provided little benefit to …
Cellular plasticity and the neuroendocrine phenotype in prostate cancer
The success of next-generation androgen receptor (AR) pathway inhibitors, such as
abiraterone acetate and enzalutamide, in treating prostate cancer has been hampered by …
abiraterone acetate and enzalutamide, in treating prostate cancer has been hampered by …
[HTML][HTML] Clinical significance of androgen receptor splice variant-7 mRNA detection in circulating tumor cells of men with metastatic castration-resistant prostate cancer …
Purpose We reported previously that the detection of androgen receptor splice variant-7 (AR-
V7) mRNA in circulating tumor cells (CTCs) correlated with poor outcomes from the use of …
V7) mRNA in circulating tumor cells (CTCs) correlated with poor outcomes from the use of …
LuCaP prostate cancer patient‐derived xenografts reflect the molecular heterogeneity of advanced disease and serve as models for evaluating cancer therapeutics
HM Nguyen, RL Vessella, C Morrissey, LG Brown… - The …, 2017 - Wiley Online Library
BACKGROUND Metastatic prostate cancer is a common and lethal disease for which there
are no therapies that produce cures or long‐term durable remissions. Clinically relevant …
are no therapies that produce cures or long‐term durable remissions. Clinically relevant …
Targeting angiogenesis in prostate cancer
Z Melegh, S Oltean - International journal of molecular sciences, 2019 - mdpi.com
Prostate cancer is the most commonly diagnosed cancer among men in the Western world.
Although localized disease can be effectively treated with established surgical and …
Although localized disease can be effectively treated with established surgical and …
Alternative splicing in prostate cancer
A Paschalis, A Sharp, JC Welti, A Neeb… - Nature reviews Clinical …, 2018 - nature.com
Androgen receptor (AR) splice variants (AR-Vs) have been implicated in the development
and progression of metastatic prostate cancer. AR-Vs are truncated isoforms of the AR, a …
and progression of metastatic prostate cancer. AR-Vs are truncated isoforms of the AR, a …
ARe we there yet? Understanding androgen receptor signaling in breast cancer
AR Michmerhuizen, DE Spratt, LJ Pierce… - NPJ breast cancer, 2020 - nature.com
The role of androgen receptor (AR) activation and expression is well understood in prostate
cancer. In breast cancer, expression and activation of AR is increasingly recognized for its …
cancer. In breast cancer, expression and activation of AR is increasingly recognized for its …