Introduction: The bromodomain and extra-terminal (BET) family of proteins are epigenetic
readers of acetylated histones regulating a vast network of protein expression across many …

Purpose Liquid biopsy refers to the detection and analysis of the components from biological
fluids non-invasively, including circulating tumor cells, nucleic acids, and extracellular …

Background Echinococcus multilocularis causes alveolar echinococcosis (AE), a rising
zoonotic disease in the northern hemisphere. Treatment of this fatal disease is limited to …

Synthetic analogues of the marine natural product sintokamides have been prepared in
order to investigate the structure–activity relationships for the androgen receptor N-terminal …

BACKGROUND Currently, the role of UPR signaling in prostate cancer (PCa) is unclear. To
evaluate the relationship between UPR signaling pathway and the prognosis of PCa, we …

Objective: Prostate cancer (PCa) is the most common malignant tumor diagnosed in men in
developed countries. In developing countries, the PCa morbidity and mortality rates are also …

Melatonin is an endogenous indolamine, synthesized and secreted from the pineal gland.
The environmental light-dark cycle is the primary regulator of melatonin synthesis. Darkness …

We designed and synthesized novel 4-acetoxypentanamide derivatives of spliceostatin A,
whose 4-acetoxypentenamide moiety is reduced (7), isomerized (8), or substituted with …

Although several therapeutic options have been shown to improve survival of most patients
with prostate cancer, progression to castration-refractory state continues to present …

The gonadoblastoma gene, testis-specific protein Y-encoded (TSPY), on the Y chromosome
and its X-homologue, TSPX, are cell cycle regulators and function as a proto-oncogene and …