Nonpreferential but Detrimental Accumulation of Macrophages With Clonal Hematopoiesis-Driver Mutations in Cardiovascular Tissues—Brief Report

TS Dederichs, A Yerdenova, H Horstmann… - … , and vascular biology, 2024 - Am Heart Assoc
BACKGROUND: Clonal hematopoiesis of indeterminate potential (CHIP) is an acquired
genetic risk factor for both leukemia and cardiovascular disease. It results in proinflammatory …

Clonal haematopoiesis across the age spectrum of vasculitis patients with Takayasu's arteritis, ANCA-associated vasculitis and giant cell arteritis

F Gutierrez-Rodrigues, KV Wells, AI Jones… - Annals of the …, 2024 - ard.bmj.com
Objectives Ageing and inflammation are associated with clonal haematopoiesis (CH), the
emergence of somatic mutations in haematopoietic cells. This study details CH in patients …