Ovarian aging in women correlates with the progressive loss of both the number and quality
of oocytes. When these processes occur early or are accelerated, their clinical correlates are …

The preservation of genome integrity in the mammalian female germline from primordial
follicle arrest to activation of growth to oocyte maturation is fundamental to ensure …

The ovarian system comprises vital organs in females and is of great significance for the
maintenance of reproductive potential and endocrine stability. Although complex …

Normal levels of reactive oxygen species (ROS) play an important role in regulating follicular
growth, angiogenesis and sex hormone synthesis in ovarian tissue. When the balance …

Polycystic ovarian syndrome (PCOS) is one of the leading causes of anovulatory infertility in
women, affecting 5%–15% of women of reproductive age worldwide. The clinical …

Abstract Peroxiredoxin 4 (Prdx4), a member of the Prdx family, is a vital ER-resident
antioxidant in cells. As revealed in our previous study, Prdx4 expression was detected in …

Abstract Sirtuin-3 (SIRT3), the main deacetylase in the mitochondria, maintains cellular
energy metabolism and redox balance by deacetylating mitochondrial proteins in a NAD+ …

Oxidative stress has been implicated in the pathophysiology of numerous terrestrial disease
processes and associated with morbidity following spaceflight. Furthermore, oxidative stress …

Mitochondria have been implicated as key factors regulating female reproductive processes.
Notable progress has been made in determining the role of mitochondria with respect to …

Air pollution has been an important risk factor for female reproductive health. However,
epidemiological evidence of ambient air pollution on the predictor for ovarian reserve (antral …