Therapy resistance remains a huge challenge for current breast cancer treatments.
Exploring molecular mechanisms of therapy resistance might provide therapeutic targets for …

Diabetes mellitus (DM), is the most common metabolic disease and is characterized by
sustained hyperglycemia. Accumulating evidences supports a strong association between …

Background The expression of CYP4Z1 and the pseudogene CYP4Z2P has been shown to
be specifically increased in breast cancer by our group and others. Additionally, we …

Background Drug resistance continues to be a major limiting factor across diverse anti-
cancer therapies. Contributing to the complexity of this challenge is cancer plasticity, in …

Radiosensitizers are compounds or nanostructures, which can improve the efficiency of
ionizing radiation to kill cells. Radiosensitization increases the susceptibility of cancer cells …

Ovarian cancer (OC) is a major cause of cancer-related deaths in women all over the world.
The easy metastasis of OC and the problem of radioresistance are serious issues remaining …

Selective downregulation of the human antigen R (HuR) protein by siRNA may provide a
powerful approach for treating lung cancer. To this end, we investigated the efficacy of …

Human antigen (Hu) R is an RNA-binding protein whose overexpression in human cancer
correlates with aggressive disease, drug resistance, and poor prognosis. HuR inhibition has …

Gene silencing through RNA interference (RNAi) has emerged as a potential strategy in
manipulating cancer causing genes by complementary base-pairing mechanism. Small …

Radioresistance of tumor cells gives rise to local recurrence and disease progression in
many patients. MicroRNAs (miRNAs) are master regulators of gene expression that control …