The opioid crisis: a comprehensive overview

N Vadivelu, AM Kai, V Kodumudi, J Sramcik… - Current pain and …, 2018 - Springer
Abstract Purpose of Review The opioid crisis most likely is the most profound public health
crisis our nation has faced. In 2015 alone, 52,000 people died of drug overdoses, with over …

The rising tide of opioid use and abuse: the role of the anesthesiologist

EJ Koepke, EL Manning, TE Miller, A Ganesh… - Perioperative …, 2018 - Springer
Opioid use has risen dramatically in the past three decades. In the USA, opioid overdose
has become a leading cause of unintentional death, surpassing motor vehicle accidents. A …

Prediction of opioid-induced respiratory depression on inpatient wards using continuous capnography and oximetry: an international prospective, observational trial

AK Khanna, SD Bergese, CR Jungquist… - Anesthesia & …, 2020 - journals.lww.com
BACKGROUND: Opioid-related adverse events are a serious problem in hospitalized
patients. Little is known about patients who are likely to experience opioid-induced …

Apollo‐2: a randomized, placebo and active‐controlled phase III study investigating oliceridine (TRV 130), a G protein–biased ligand at the μ‐opioid receptor, for …

NK Singla, F Skobieranda, DG Soergel… - Pain …, 2019 - Wiley Online Library
Objectives The clinical utility of conventional IV opioids is limited by the occurrence of opioid‐
related adverse events. Oliceridine is a novel G protein–biased μ‐opioid receptor agonist …

Efficacy of smartphone active and passive virtual reality distraction vs standard care on burn pain among pediatric patients: a randomized clinical trial

H Xiang, J Shen, KK Wheeler, J Patterson… - JAMA Network …, 2021 - jamanetwork.com
Importance It is unknown whether smartphone-based virtual reality (VR) games are effective
in reducing pain among pediatric patients in real-world burn clinics. Objective To evaluate …

Association of opioid-related adverse drug events with clinical and cost outcomes among surgical patients in a large integrated health care delivery system

S Shafi, AW Collinsworth, LA Copeland… - JAMA …, 2018 - jamanetwork.com
Importance Opioids are commonly used for pain control during and after invasive
procedures. However, opioid-related adverse drug events (ORADEs) are common and have …

Association of multimodal pain management strategies with perioperative outcomes and resource utilization: a population-based study

SG Memtsoudis, J Poeran, N Zubizarreta… - …, 2018 - pubs.asahq.org
Background Multimodal analgesia is increasingly considered routine practice in joint
arthroplasties, but supportive large-scale data are scarce. The authors aimed to determine …

Prevalence of preoperative opioid use and characteristics associated with opioid use among patients presenting for surgery

PE Hilliard, J Waljee, S Moser, L Metz, M Mathis… - JAMA …, 2018 - jamanetwork.com
Importance Patterns of preoperative opioid use are not well characterized across different
surgical services, and studies in this patient population have lacked important self-reported …

Chronic opioid usage in surgical patients in a large academic center

X Jiang, M Orton, R Feng, E Hossain… - Annals of …, 2017 - journals.lww.com
Objective: The objective of this study is to investigate the prevalence and disparity of chronic
opioid usage in surgical patients and the potential risk factors associated with chronic opioid …

[HTML][HTML] Local infiltration analgesia with liposomal bupivacaine improves pain scores and reduces opioid use after total knee arthroplasty: results of a randomized …

MA Mont, WB Beaver, SH Dysart, JW Barrington… - The Journal of …, 2018 - Elsevier
Background Local infiltration analgesia (LIA) with liposomal bupivacaine (LB) in patients
undergoing total knee arthroplasty (TKA) has yielded mixed results. The PILLAR study …