Overview of oral cavity squamous cell carcinoma: Risk factors, mechanisms, and diagnostics

A Chamoli, AS Gosavi, UP Shirwadkar, KV Wangdale… - Oral oncology, 2021 - Elsevier
Oral cavity squamous cell carcinoma (OCSCC) is the most common malignancy of the oral
cavity. The substantial risk factors for OCSCC are the consumption of tobacco products …

Current trends of targeted therapy for oral squamous cell carcinoma

H Li, Y Zhang, M Xu, D Yang - Journal of cancer research and clinical …, 2022 - Springer
Oral squamous cell carcinoma (OSCC) is a malignant disease in the world which has a
profound effect on human health and life quality. According to tumor stage and pathological …

[HTML][HTML] The molecular basis and therapeutic aspects of cisplatin resistance in oral squamous cell carcinoma

Y Cheng, S Li, L Gao, K Zhi, W Ren - Frontiers in oncology, 2021 - frontiersin.org
Oral squamous cell carcinoma (OSCC) is a kind of malignant tumors with low survival rate
and prone to have early metastasis and recurrence. Cisplatin is an alkylating agent which …

Spatial transcriptomics reveals distinct and conserved tumor core and edge architectures that predict survival and targeted therapy response

R Arora, C Cao, M Kumar, S Sinha, A Chanda… - Nature …, 2023 - nature.com
The spatial organization of the tumor microenvironment has a profound impact on biology
and therapy response. Here, we perform an integrative single-cell and spatial transcriptomic …

Design, synthesis and antitumor activity of novel thiophene-triazine derivatives bearing arylurea unit as potent PI3K/mTOR inhibitorss

S Xu, L Luo, X Sun, Y Yang, Q Guo, Z Jiang… - Bioorganic & Medicinal …, 2023 - Elsevier
In this article, we designed and synthesized a series of novel thiophene-triazine derivatives
bearing arylurea unit as potent dual PI3K/mTOR inhibitors. The cytotoxicity of all the target …

NEDD4L inhibits glycolysis and proliferation of cancer cells in oral squamous cell carcinoma by inducing ENO1 ubiquitination and degradation

G Zhang, X Zhao, W Liu - Cancer Biology & Therapy, 2022 - Taylor & Francis
Glycolysis contributes to cell metabolism and facilitates cell proliferation of oral squamous
cell carcinoma (OSCC), the most common type of oral cancer. Understanding the regulatory …

Oral cavity squamous cell carcinoma: an update of the pharmacological treatment

M Imbesi Bellantoni, G Picciolo, I Pirrotta, N Irrera… - Biomedicines, 2023 - mdpi.com
Oral cavity squamous cell carcinoma (OCSCC) represents a serious health and socio-
economic problem in different geographical areas of the world. It is characterized by a high …

[HTML][HTML] Cytotoxic and antioxidant effects of Phoenix dactylifera L.(Ajwa date extract) on oral squamous cell carcinoma cell line

K Shahbaz, JA Asif, T Liszen, AA Nurul… - BioMed Research …, 2022 - hindawi.com
Aim. The aim of the current study is to investigate the antioxidant and apoptotic potential of
Ajwa date flesh (ADF) and Ajwa date pit (ADP) extract on human squamous cell carcinoma …

Bioactive phytocompounds for oral cancer prevention and treatment: A comprehensive and critical evaluation

JT Burcher, LK DeLiberto, AM Allen… - Medicinal Research …, 2023 - Wiley Online Library
The high incidence of oral cancer combined with excessive treatment cost underscores the
need for novel oral cancer preventive and therapeutic options. The value of natural agents …

Identification of latent biomarkers in connection with progression and prognosis in oral cancer by comprehensive bioinformatics analysis

A Reyimu, Y Chen, X Song, W Zhou, J Dai… - World Journal of Surgical …, 2021 - Springer
Background Oral cancer (OC) is a common and dangerous malignant tumor with a low
survival rate. However, the micro level mechanism has not been explained in detail …