There is substantial variation between individuals in the immune response to vaccination. In
this review, we provide an overview of the plethora of studies that have investigated factors …

Neonates have an immature immune system, which cannot adequately protect against
infectious diseases. Early in life, immune protection is accomplished by maternal antibodies …

This report is a compendium of all current recommendations for the prevention of measles,
rubella, congenital rubella syndrome (CRS), and mumps. The report presents the recent …

Placental transfer of maternal IgG antibodies to the fetus is an important mechanism that
provides protection to the infant while his/her humoral response is inefficient. IgG is the only …

The past decade has brought great strides in our understanding of adaptive immunity in
neonatal mice. Although poor immune responses are commonly observed, it is now clear …

Mumps is a common childhood infection caused by the mumps virus. The hallmark of
infection is swelling of the parotid gland. Aseptic meningitis and encephalitis are common …

Infants are capable of mounting adaptive immune responses, but their ability to develop long-
lasting immunity is limited. Understanding the particularities of the neonatal adaptive …

The persistence of serum IgG antibodies elicited in human infants is much shorter than when
such responses are elicited later in life. The reasons for this rapid waning of antigen-specific …

Infant immunization is the most cost-effective strategy to prevent infectious diseases in
childhood, but is limited by immaturity of the immune system. To define strategies to improve …

A measles outbreak occurred in New York City. All cases had prior evidence of measles
immunity. Symptoms were consistent with measles. Laboratory results indicated secondary …