CME Harvard Review of Psychiatry offers CME for readers who complete questions about
featured articles. Questions can be accessed from the Harvard Review of Psychiatry website …

The rapid expansion of the elderly population has led to the recent epidemic of age-related
diseases, including increased incidence and mortality of chronic and acute lung diseases …

Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality worldwide.
We performed a genetic association study in 15,256 cases and 47,936 controls, with …

Background Understanding the genetic basis of airflow obstruction and smoking behaviour
is key to determining the pathophysiology of chronic obstructive pulmonary disease (COPD) …

Quantitative traits analyzed in Genome-Wide Association Studies (GWAS) are often
nonnormally distributed. For such traits, association tests based on standard linear …

The identification of small molecules that target specific CFTR variants has ushered in a new
era of treatment for cystic fibrosis (CF), yet optimal, individualized treatment of CF will require …

Background The genetic risk factors for susceptibility to chronic obstructive pulmonary
disease (COPD) are still largely unknown. Additional genetic variants are likely to be …

Abstract The Rotterdam Study is a prospective cohort study ongoing since 1990 in the city of
Rotterdam in The Netherlands. The study targets cardiovascular, endocrine, hepatic …

Myopia is the most common human eye disorder and it results from complex genetic and
environmental causes. The rapidly increasing prevalence of myopia poses a major public …

Forced vital capacity (FVC), a spirometric measure of pulmonary function, reflects lung
volume and is used to diagnose and monitor lung diseases. We performed genome-wide …