Developing reliable, predictive animal models for complex psychiatric disorders, such as
schizophrenia, is essential to increase our understanding of the neurobiological basis of the …

Many of the brain's reward systems converge on the nucleus accumbens, a region richly
innervated by excitatory, inhibitory, and modulatory afferents representing the circuitry …

Mental illness modeling is still a major challenge for scientists. Animal models of
schizophrenia are essential to gain a better understanding of the disease etiopathology and …

The dopamine hypothesis of schizophrenia is the principal explanatory model of
antipsychotic drug action. Recent discoveries extend our understanding of the …

Traditionally, animal models of schizophrenia were predominantly pharmacological
constructs focused on phenomena linked to dopamine and glutamate neurotransmitter …

Animal models play a central role in all areas of biomedical research. The process of animal
model building, development and evaluation has rarely been addressed systematically …

The 67 and 65 kDa isoforms of glutamic acid decarboxylase, the key enzymes for GABA
biosynthesis, are expressed at altered levels in postmortem brain of subjects diagnosed with …

BACKGROUND AND PURPOSE Ginsenoside Rg1 (Rg1) is one of the major bioactive
ingredients of Panax ginseng with little toxicity and has been shown to have neuroprotective …

Antipsychotics represent the mainstay of schizophrenia pharmacological therapy, and their
role has been expanded in the last years to mood disorders treatment. Although introduced …

Chronic stress produces consistent and reversible changes within the dendritic arbors of
CA3 hippocampal neurons, characterized by decreased dendritic length and reduced …