The 'speck'-tacular oversight of the NLRP3-pyroptosis pathway on gastrointestinal inflammatory diseases and tumorigenesis
V Arrè, R Scialpi, M Centonze, G Giannelli… - Journal of biomedical …, 2023 - Springer
The NLRP3 inflammasome is an intracellular sensor and an essential component of the
innate immune system involved in danger recognition. An important hallmark of …
innate immune system involved in danger recognition. An important hallmark of …
Pyroptosis: a double-edged sword in lung cancer and other respiratory diseases
X Liang, Y Qin, D Wu, Q Wang, H Wu - Cell Communication and Signaling, 2024 - Springer
Pyroptosis is an active cell death process mediated by gasdermin family proteins including
Gasdermin A (GSDMA), Gasdermin B (GSDMB), Gasdermin C (GSDMC), Gasdermin D …
Gasdermin A (GSDMA), Gasdermin B (GSDMB), Gasdermin C (GSDMC), Gasdermin D …
An underutilized bean: hyacinth bean [Lablab purpureus (L.) sweet]: bioactive compounds, functional activity, and future food prospect and applications
J Zhou, W Wang, Z Zhang, G Zhu, J Qiao… - Journal of the …, 2024 - Wiley Online Library
Hyacinth bean [Lablab purpureus (L.) Sweet], a plant belonging to the leguminous family
and traditionally used for medicinal purposes in China, is a valuable resource with a wide …
and traditionally used for medicinal purposes in China, is a valuable resource with a wide …
Enhanced cytokine signaling and ferroptosis defense interplay initiates obesity-associated pancreatic ductal adenocarcinoma
R Ruze, Y Chen, J Song, R Xu, X Yin, Q Xu, C Wang… - Cancer Letters, 2024 - Elsevier
Obesity is a significant risk factor for various cancers, including pancreatic cancer (PC), but
the underlying mechanisms are still unclear. In our study, pancreatic ductal epithelial cells …
the underlying mechanisms are still unclear. In our study, pancreatic ductal epithelial cells …
Chromodomain Y‐like (CDYL) inhibition ameliorates acute kidney injury in mice by regulating tubular pyroptosis
T Xiang, L Li, J Li, X Chen, F Guo, J Liu, Y Wu… - Acta Pharmacologica …, 2024 - nature.com
Acute kidney injury (AKI) is a common disease, but lacking effective drug treatments.
Chromodomain Y‐like (CDYL) is a kind of chromodomain protein that has been implicated …
Chromodomain Y‐like (CDYL) is a kind of chromodomain protein that has been implicated …
Investigating the causal association between obesity and risk of hepatocellular carcinoma and underlying mechanisms
Z Chen, C Ding, K Chen, Y Gu, X Qiu, Q Li - Scientific Reports, 2024 - nature.com
Obesity is a global health concern and independent risk factor for cancers including
hepatocellular carcinoma (HCC). However, evidence on the causal links between obesity …
hepatocellular carcinoma (HCC). However, evidence on the causal links between obesity …
Investigating the Role of FABP4 in Diabetes and Obesity and the Influence of Age and Ethnicity: A Comprehensive Analysis of a Cohort from the KEDP-Study
Adipocyte P2 (aP2), also known as FABP4, is an adipokine that adipose tissue produces
and expresses in macrophages. Its primary role is to facilitate the transportation of fatty acids …
and expresses in macrophages. Its primary role is to facilitate the transportation of fatty acids …
Global Burden of Pancreatic Cancer Attributable to High Body-Mass Index in 204 Countries and Territories, 1990–2019
Simple Summary The burden of pancreatic cancer attributable to a high body mass index
(BMI) increased significantly for both sexes, in all ages, across all socio-demographic index …
(BMI) increased significantly for both sexes, in all ages, across all socio-demographic index …
KIF23 promotes cervical cancer progression via inhibiting NLRP3‐mediated pyroptosis
X Liu, X Xie, Q Li, X Xie, M Xiong, W Han… - The FASEB …, 2024 - Wiley Online Library
Background Cervical cancer (CC), closely linked to persistent human papillomavirus
infection, represents a major health problem for women worldwide. The objective of this …
infection, represents a major health problem for women worldwide. The objective of this …
[HTML][HTML] Precise targeting of lipid metabolism in the era of immuno-oncology and the latest advances in nano-based drug delivery systems for cancer therapy
H Zhang, Y Li, J Huang, L Shen, Y Xiong - Acta Pharmaceutica Sinica B, 2024 - Elsevier
Over the past decade, research has increasingly identified unique dysregulations in lipid
metabolism within the tumor microenvironment (TME). Lipids, diverse biomolecules, not only …
metabolism within the tumor microenvironment (TME). Lipids, diverse biomolecules, not only …