The form, function, and evolutionary significance of neural aromatization

BA Schlinger, L Remage-Healey… - Frontiers in …, 2022 - Elsevier
Songbirds have emerged as exceptional research subjects for helping us appreciate and
understand estrogen synthesis and function in brain. In the context of recognizing the …

Brain-generated estradiol drives long-term optimization of auditory coding to enhance the discrimination of communication signals

LA Tremere, R Pinaud - Journal of Neuroscience, 2011 - Soc Neuroscience
Auditory processing and hearing-related pathologies are heavily influenced by steroid
hormones in a variety of vertebrate species, including humans. The hormone estradiol has …

Interactions between neuroactive steroids and reelin haploinsufficiency in Purkinje cell survival

F Biamonte, G Assenza, R Marino, M D'Amelio… - Neurobiology of …, 2009 - Elsevier
We determined total Purkinje cell (PC) numbers in cerebella of wild-type (+/+) and
heterozygous (rl/+) reeler mice of either sex during early postnatal development; in parallel …

Ultrasensitive quantification of multiple estrogens in songbird blood and microdissected brain by LC-MS/MS

C Jalabert, MA Shock, C Ma, TJ Bootsma, MQ Liu… - Eneuro, 2022 - eneuro.org
Neuroestrogens are synthesized within the brain and regulate social behavior, learning and
memory, and cognition. In song sparrows, Melospiza melodia, 17β-estradiol (17β-E2) …

A membrane G-protein-coupled estrogen receptor is necessary but not sufficient for sex differences in zebra finch auditory coding

AA Krentzel, M Macedo-Lima, MZ Ikeda… - …, 2018 - academic.oup.com
Estradiol acts as a neuromodulator in brain regions important for cognition and sensory
processing. Estradiol also shapes brain sex differences but rarely have these concepts been …

Genes located in a chromosomal inversion are correlated with territorial song in white‐throated sparrows

WM Zinzow‐Kramer, BM Horton… - Genes, Brain and …, 2015 - Wiley Online Library
The genome of the white‐throated sparrow (Zonotrichia albicollis) contains an inversion
polymorphism on chromosome 2 that is linked to predictable variation in a suite of …

Concepts derived from the challenge hypothesis

JC Wingfield, W Goymann, C Jalabert, KK Soma - Hormones and behavior, 2019 - Elsevier
Abstract The Challenge Hypothesis was developed to explain why and how regulatory
mechanisms underlying patterns of testosterone secretion vary so much across species and …

Presynaptic control of rapid estrogen fluctuations in the songbird auditory forebrain

L Remage-Healey, S Dong, NT Maidment… - Journal of …, 2011 - Soc Neuroscience
Within the CNS of vertebrates, estrogens can directly modulate neural circuits that govern a
wide range of behaviors, including feeding, spatial navigation, reproduction, and auditory …

Rising StARs: behavioral, hormonal, and molecular responses to social challenge and opportunity

LS Huffman, MM Mitchell, LA O'Connell… - Hormones and …, 2012 - Elsevier
Across taxa, individuals must respond to a dynamic social environment of challenges and
opportunities on multiple biological levels, including behavior, hormone profiles, and gene …

Distribution of aromatase in the brain of the African cichlid fish Astatotilapia burtoni: Aromatase expression, but not estrogen receptors, varies with female reproductive …

KP Maruska, JM Butler, C Anselmo… - Journal of …, 2020 - Wiley Online Library
Estrogen synthesis and signaling in the brains of vertebrates has pleotropic effects ranging
from neurogenesis to modulation of behaviors. The majority of studies on brain‐derived …