Genetic factors strongly affect susceptibility to common diseases and also influence disease-
related quantitative traits. Identifying the relevant genes has been difficult, in part because …

In this review we describe the principles, protocols, and applications of two commercially
available SNP genotyping platforms, the TaqMan® SNP Genotyping Assays and the …

We conducted a genome-wide association study (GWAS) and a genome-wide gene-
environment interaction analysis of esophageal squamous-cell carcinoma (ESCC) in 2,031 …

Admixture mapping (also known as" mapping by admixture linkage disequilibrium," or
MALD) provides a way of localizing genes that cause disease, in admixed ethnic groups …

To support large-scale biomedical research projects, organizations need to share person-
specific genomic sequences without violating the privacy of their data subjects. In the past …

We have previously shown that natural cytotoxic activity of peripheral blood lymphocytes
was inversely related to cancer development based on a prospective cohort study. The …

Vascular access thrombosis is the most common and costly complication in hemodialysis
patients. The role of thrombophilia in access thrombosis is not established. A case-control …

It is widely hoped that the study of sequence variation in the human genome will provide a
means of elucidating the genetic component of complex diseases and variable drug …

A central question in evolutionary biology is how interactions between organisms and the
environment shape genetic differentiation. The pathogen Batrachochytrium dendrobatidis …

Linkage disequilibrium was estimated using 7119 single nucleotide polymorphism markers
across the genome and 200 animals from the North American Holstein cattle population …