The SLC38A5/SNAT5 amino acid transporter: from pathophysiology to pro-cancer roles in the tumor microenvironment
G Taurino, M Chiu, MG Bianchi… - American Journal of …, 2023 - journals.physiology.org
SLC38A5/SNAT5 is a system N transporter that can mediate net inward or outward
transmembrane fluxes of neutral amino acids coupled with Na+ (symport) and H+ (antiport) …
transmembrane fluxes of neutral amino acids coupled with Na+ (symport) and H+ (antiport) …
[HTML][HTML] Intestinal amino acid transport and metabolic health
S Bröer - Annual review of nutrition, 2023 - annualreviews.org
Amino acids derived from protein digestion are important nutrients for the growth and
maintenance of organisms. Approximately half of the 20 proteinogenic amino acids can be …
maintenance of organisms. Approximately half of the 20 proteinogenic amino acids can be …
[HTML][HTML] Induction of oxidative stress and ferroptosis in triple-negative breast cancer cells by niclosamide via blockade of the function and expression of SLC38A5 and …
M Mathew, S Sivaprakasam… - Antioxidants, 2024 - mdpi.com
The amino acid transporters SLC38A5 and SLC7A11 are upregulated in triple-negative
breast cancer (TNBC). SLC38A5 transports glutamine, methionine, glycine and serine, and …
breast cancer (TNBC). SLC38A5 transports glutamine, methionine, glycine and serine, and …
[HTML][HTML] Shared metabolic shifts in endothelial cells in stroke and Alzheimer's disease revealed by integrated analysis
G Guo, L Fan, Y Yan, Y Xu, Z Deng, M Tian, Y Geng… - Scientific Data, 2023 - nature.com
Since metabolic dysregulation is a hallmark of both stroke and Alzheimer's disease (AD),
mining shared metabolic patterns in these diseases will help to identify their possible …
mining shared metabolic patterns in these diseases will help to identify their possible …
[HTML][HTML] Potent inhibition of macropinocytosis by niclosamide in cancer cells: a novel mechanism for the anticancer efficacy for the antihelminthic
SR Sennoune, GD Nandagopal, S Ramachandran… - Cancers, 2023 - mdpi.com
Simple Summary Niclosamide, a drug used to treat tapeworm infection, has been shown to
have potential as an anticancer drug. The mechanism proposed for this action is the drug …
have potential as an anticancer drug. The mechanism proposed for this action is the drug …
[HTML][HTML] Immunogenetic aspects of sarcopenic obesity
Ł Mazurkiewicz, K Czernikiewicz, B Grygiel-Górniak - Genes, 2024 - mdpi.com
Sarcopenic obesity (SO) is a combination of obesity and sarcopenia, with diagnostic criteria
defined as impaired skeletal muscle function and altered body composition (eg, increased …
defined as impaired skeletal muscle function and altered body composition (eg, increased …
Impact of Oncogenic Changes in p53 and KRAS on Macropinocytosis and Ferroptosis in Colon Cancer Cells and Anticancer Efficacy of Niclosamide with Differential …
NT Nguyen, SR Sennoune… - Cells, 2024 - mdpi.com
Mutations in p53 and KRAS are seen in most cases of colon cancer. The impact of these
mutations on signaling pathways related to cancer growth has been studied in depth, but …
mutations on signaling pathways related to cancer growth has been studied in depth, but …
Intermediate metabolites and molecular correlates of one‑carbon and nutrient metabolism differ in tissues from Holstein fetuses
AA Aboragah, DN Sherlock, N Wichasit, J Mauck… - Research in Veterinary …, 2023 - Elsevier
Methionine and folate cycles along with transsulfuration comprise the one‑carbon
metabolism (OCM) pathway. Amino acids and other nutrients feed into OCM, which is central …
metabolism (OCM) pathway. Amino acids and other nutrients feed into OCM, which is central …
Identification of Key Genes and Biological Pathways in Bipolar Disorder by Bioinformatics and Next Generation Sequencing Data Analysis
B Vastrad, C Vastrad - bioRxiv, 2022 - biorxiv.org
Bipolar disorder (BD), also known as psychiatric disorder, affects millions of people all over
the world. The aim of this investigation was to screen and verify hub genes involved in BD as …
the world. The aim of this investigation was to screen and verify hub genes involved in BD as …
[PDF][PDF] Immunogenetic Aspects of Sarcopenic Obesity. Genes 2024, 15, 206
Ł Mazurkiewicz, K Czernikiewicz, B Grygiel-Górniak - 2024 - pdfs.semanticscholar.org
Sarcopenic obesity (SO) is a combination of obesity and sarcopenia, with diagnostic criteria
defined as impaired skeletal muscle function and altered body composition (eg, increased …
defined as impaired skeletal muscle function and altered body composition (eg, increased …