[HTML][HTML] The role of tristetraprolin in cancer and inflammation
S Sanduja, FF Blanco, LE Young, V Kaza… - Frontiers in bioscience …, 2012 - ncbi.nlm.nih.gov
Messenger RNA decay is a critical mechanism to control the expression of many
inflammation-and cancer-associated genes. These transcripts are targeted for rapid …
inflammation-and cancer-associated genes. These transcripts are targeted for rapid …
The roles of TTP and BRF proteins in regulated mRNA decay
S Sanduja, FF Blanco, DA Dixon - Wiley interdisciplinary …, 2011 - Wiley Online Library
Adenylate‐and uridylate‐rich element (ARE) motifs are cis‐acting elements present in the
3′ untranslated region of mRNA transcripts that encode many inflammation‐and cancer …
3′ untranslated region of mRNA transcripts that encode many inflammation‐and cancer …
The mRNA stability factor HuR inhibits microRNA-16 targeting of COX-2
LE Young, AE Moore, L Sokol, N Meisner-Kober… - Molecular Cancer …, 2012 - AACR
Commonly observed in colorectal cancer is the elevated expression of the prostaglandin
(PG) synthase COX-2. In normal intestinal epithelium, the COX-2 mRNA is targeted for rapid …
(PG) synthase COX-2. In normal intestinal epithelium, the COX-2 mRNA is targeted for rapid …
The mRNA binding proteins HuR and tristetraprolin regulate cyclooxygenase 2 expression during colon carcinogenesis
LE Young, S Sanduja, K Bemis–Standoli, EA Pena… - Gastroenterology, 2009 - Elsevier
BACKGROUND & AIMS: During tumorigenesis, loss of rapid messenger RNA (mRNA)
decay allows for overexpression of cancer-associated genes. The RNA-binding proteins Hu …
decay allows for overexpression of cancer-associated genes. The RNA-binding proteins Hu …
[HTML][HTML] Post-transcriptional control during chronic inflammation and cancer: a focus on AU-rich elements
KSA Khabar - Cellular and molecular life sciences, 2010 - Springer
A considerable number of genes that code for AU-rich mRNAs including cytokines, growth
factors, transcriptional factors, and certain receptors are involved in both chronic …
factors, transcriptional factors, and certain receptors are involved in both chronic …
[HTML][HTML] Impact of HuR inhibition by the small molecule MS-444 on colorectal cancer cell tumorigenesis
FF Blanco, R Preet, A Aguado, V Vishwakarma… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Colorectal cancer (CRC) is the third most common cancer and a leading cause of cancer-
related mortality. Observed during CRC tumorigenesis is loss of post-transcriptional …
related mortality. Observed during CRC tumorigenesis is loss of post-transcriptional …
Mechanistic aspects of COX-2 expression in colorectal neoplasia
Abstract The cyclooxygenase-2 (COX-2) enzyme catalyzes the rate-limiting step of
prostaglandin formation in pathogenic states and a large amount of evidence has …
prostaglandin formation in pathogenic states and a large amount of evidence has …
Hallmarks of cancer and AU‐rich elements
KSA Khabar - Wiley Interdisciplinary Reviews: RNA, 2017 - Wiley Online Library
Post‐transcriptional control of gene expression is aberrant in cancer cells. Sustained
stabilization and enhanced translation of specific mRNAs are features of tumor cells. AU …
stabilization and enhanced translation of specific mRNAs are features of tumor cells. AU …
Angiogenesis and current antiangiogenic strategies for the treatment of cancer
Angiogenesis is a complex process critical for embryonic development and for survival. It is
also a critical player in many pathologic processes, most notably in neoplasia. The cell …
also a critical player in many pathologic processes, most notably in neoplasia. The cell …
Regulatory module involving FGF13, miR-504, and p53 regulates ribosomal biogenesis and supports cancer cell survival
The microRNA miR-504 targets TP53 mRNA encoding the p53 tumor suppressor. miR-504
resides within the fibroblast growth factor 13 (FGF13) gene, which is overexpressed in …
resides within the fibroblast growth factor 13 (FGF13) gene, which is overexpressed in …