Recent advances in Staphylococcus aureus infection: focus on vaccine development

S Ansari, RK Jha, SK Mishra, BR Tiwari… - Infection and drug …, 2019 - Taylor & Francis
Staphylococcus aureus normally colonizes the nasal cavity and pharynx. After breaching the
normal habitat, the organism is able to cause a number of infections at any site of the body …

Understanding mechanisms of virulence in MRSA: implications for antivirulence treatment strategies

RC Hsieh, R Liu, DJ Burgin, M Otto - Expert Review of Anti-infective …, 2023 - Taylor & Francis
ABSTRACT Introduction Methicillin-resistant Staphylococcus aureus (MRSA) is a
widespread pathogen, often causing recurrent and deadly infections in the hospital and …

[HTML][HTML] Staphylococcus aureus vaccine strategy: promise and challenges

U Chand, P Priyambada, PK Kushawaha - Microbiological Research, 2023 - Elsevier
Staphylococcus aureus (S. aureus) is a leading and crucial infectious threat to global public
health due to the widespread emergence of antibiotic-resistant strains such as Methicillin …

[HTML][HTML] Transcutaneous immunization of recombinant Staphylococcal enterotoxin B protein using a dissolving microneedle provides potent protection against lethal …

S Liu, S Zhang, Y Duan, Y Niu, H Gu, Z Zhao, S Zhang… - Vaccine, 2019 - Elsevier
Staphylococcal enterotoxin B (SEB) produced by the Staphylococcus aureus bacteriumis
most commonly associated with food poisoning and is known to also cause toxic shock …

Staphylococcal enterotoxin B as DNA vaccine against breast cancer in a murine model

R Halabian, A Jahangiri, H Sedighian, E Behzadi… - International …, 2023 - Springer
Recently, many efforts have been made to treat cancer using recombinant bacterial toxins
and this strategy has been used in clinical trials of various cancers. Therapeutic DNA cancer …

Dietary supplementation with spray-dried animal plasma improves vaccine protection in aged mice

L Miró, C Rosell-Cardona, C Amat, J Polo… - Frontiers in …, 2023 - frontiersin.org
Background Senescence is characterized by an aggravated inflammatory state that reduces
vaccine responsiveness. Dietary supplementation with spray-dried porcine plasma (SDP) …

SEC is an antiangiogenic virulence factor that promotes Staphylococcus aureus endocarditis independent of superantigen activity

KJ Kinney, SS Tang, XJ Wu, PM Tran… - Science …, 2022 - science.org
The superantigen staphylococcal enterotoxin C (SEC) is critical for Staphylococcus aureus
infective endocarditis (SAIE) in rabbits. Superantigenicity, its hallmark function, was …

Oral administration of recombinant Bacillus subtilis spores expressing mutant staphylococcal enterotoxin B provides potent protection against lethal enterotoxin …

Z Xiong, J Mai, F Li, B Liang, S Yao, Z Liang, C Zhang… - AMB Express, 2020 - Springer
Pathogenicity of Staphylococcus aureus is induced by staphylococcal enterotoxin B (SEB). A
mutant form of SEB (mSEB) is immunogenic as well as less toxic. Recombinant mSEB and …

[HTML][HTML] Identification of CD4+ T cell epitopes from Staphylococcus aureus secretome using immunoinformatic prediction and molecular docking

D Francis, A Kumar, S Chittalakkottu - BioTechnologia, 2021 - ncbi.nlm.nih.gov
One major reason for the lack of clinical success of Staphylococcus aureus vaccine
candidates is the inability of the antigens to develop a CD4+ T cell-mediated immune …

[PDF][PDF] 金黄色葡萄球菌肠毒素B 功能表位及中和抗体研究进展

胡乃静, 罗龙龙, 乔春霞… - 中国药理学与毒理学杂志, 2020 - cjpt.magtechjournal.com
金黄色葡萄球菌(金葡菌) 肠毒素B (SEB), 是造成食物中毒乃至中毒性休克综合征的主要病因.
SEB 也是一种超级抗原, 可以刺激T 细胞, 能够同时与抗原呈递细胞上的主要组织相容性复合物 …