The importance of platinum drugs in cancer chemotherapy is underscored by the clinical
success of cisplatin [cis-diamminedichloroplatinum (II)] and its analogues and by clinical …

Despite the widespread use of antineoplastic platinum drugs, a number of accompanying
disadvantages exist. In connection with attempts to circumvent these problems new platinum …

Substitution of NH3 by a range of amines in trans‐[PtCl2 (NH3) 2] produces compounds with
cytotoxicity significantly improved over the parent transplatin and in many cases equivalent …

In this paper we summarize the work on the development of trans-platinum complexes as
antitumor agents during the last 15 years. We review the structures and chemical properties …

We analyzed DNA duplexes modified at central guanine residues by monofunctional Ru (II)
arene complexes [(η 6-arene) Ru (II)(en)(Cl)]+(arene= tetrahydroanthracene or p-cymene …

Platinum diam (m) ine complexes, such as cisplatin, are successful anticancer drugs, but
suffer from problems of resistance and side‐effects. Photoactivatable PtIV prodrugs offer the …

Cancer is a long-known incurable disease, and the medical use of cisplatin has been a
significant discovery. However, the side-effects of cisplatin necessitate the development of …

The different antitumor and other biological effects of the third‐generation antitumor platinum
drug oxaliplatin [(1R, 2R‐diamminocyclohexane) oxalatoplatinum (ii)] in comparison with …

The structure–pharmacological activity relationships generally accepted for antitumor
platinum compounds stressed the necessity for the cis‐[PtX 2 (amine) 2] structure while the …

The PtIV diazido complex trans, trans, trans-[Pt (N3) 2 (OH) 2 (pyridine) 2](1) is unreactive in
the dark but is cytotoxic when photoactivated by UVA and visible light. We have shown that 1 …