Lactate acts as a 'buffer'between glycolysis and oxidative metabolism. In addition to being
exchanged as a fuel by the monocarboxylate transporters (MCTs) between cells and tissues …

Concussion (mild traumatic brain injury [TBI]), particularly with organized sports, has come to
the forefront of popular culture. Affecting about 1.6 million to 3.8 million athletes a year, its …

The magnitude of damage to cerebral tissues following head trauma is determined by the
primary injury, caused by the kinetic energy delivered at the time of impact, plus numerous …

The incidence of traumatic brain injury (TBI) in the United States was 3.5 million cases in
2009, according to the Centers for Disease Control and Prevention. It is a contributing factor …

Objective Traumatic brain injury (TBI) results in persistent disruption of brain metabolism that
has yet to be mechanistically defined. Early post‐traumatic seizures are one potential …

Secondary insults can adversely influence outcome following severe traumatic brain injury.
Monitoring of cerebral extracellular chemistry with microdialysis has the potential for early …

Current technologies for the point-of-care diagnosis of traumatic brain injury (TBI) lack
sensitivity, require specialist handling or involve complicated and costly procedures. Here …

With the contribution from more than one hundred CNS neurotrauma experts, this book
provides a comprehensive and up-to-date account on the latest developments in the area of …

Objectives: To analyze the effect of tight glycemic control with the use of intensive insulin
therapy on cerebral glucose metabolism in patients with severe brain injury. Design …

Objective: To determine whether nonconvulsive electrographic post-traumatic seizures
result in increases in intracranial pressure and microdialysis lactate/pyruvate ratio. Design …