Oxygen monitoring has been a topic of exhaustive study given its central role in the
biochemistry of life. The ability to quantify the physiological distribution and real‐time …

Importance Combined oxygen 15–labeled positron emission tomography (15 O PET) and
brain tissue oximetry have demonstrated increased oxygen diffusion gradients in hypoxic …

Object Oxygen delivered in supraphysiological amounts is currently under investigation as a
therapy for severe traumatic brain injury (TBI). Hyperoxia can be delivered to the brain under …

Traumatic brain injury (TBI) affects an estimated 1.7 million people in the United States and
is a contributing factor to one third of all injury related deaths annually. According to the …

Abstract During the National Neurotrauma Symposium 2010, the DG Research of the
European Commission and the National Institutes of Health/National Institute of …

BACKGROUND: Brain hypoxia (BH) can aggravate outcome after severe traumatic brain
injury (TBI). Whether BH or reduced brain oxygen (Pbto 2) is an independent outcome …

In traumatic brain injury (TBI) patients, elevation of the brain extracellular lactate
concentration and the lactate/pyruvate ratio are well-recognized, and are associated …

Oxygen extraction fraction (OEF) and the cerebral metabolic rate of oxygen (CMRO 2) are
key cerebral physiological parameters to identify at-risk cerebrovascular patients and …

Purpose Experimental evidence suggests that lactate is neuroprotective after acute brain
injury; however, data in humans are lacking. We examined whether exogenous lactate …

Traumatic brain injury (TBI) has a poorly understood pathology. Patients suffer from a variety
of physical and cognitive effects that worsen as the type of trauma worsens. Some …