The challenges posed by acute brain injury (ABI) involve the management of the initial insult
in addition to downstream inflammation, edema, and ischemia that can result in secondary …

Secondary brain injury after neurotrauma is comprised of a host of distinct, potentially
concurrent and interacting mechanisms that may exacerbate primary brain insult …

Traumatic brain injury (TBI) is an expanding public health epidemic with pathophysiology
that is difficult to diagnose and thus treat. TBI biomarkers should assess patients across …

Objective: To determine whether persistent metabolic dysfunction in normal-appearing
frontal lobe tissue is correlated with long-term tissue atrophy. Design: Prospective …

BACKGROUND: Studies in traumatic brain injury suggest that monitoring techniques such
as brain tissue oxygen (Pbto 2) and cerebral microdialysis may complement conventional …

Introduction Daily interruption of sedation (IS) has been implemented in 30 to 40% of
intensive care units worldwide and may improve outcome in medical intensive care patients …

Monitoring and management of intracranial pressure (ICP) and cerebral perfusion pressure
(CPP) is a standard of care after traumatic brain injury (TBI). However, the pathophysiology …

Objective: To determine the effect of normobaric hyperoxia on cerebral metabolism in
patients with severe traumatic brain injury. Design: Prospective clinical investigation. Setting …

Background Optimal resuscitation after traumatic brain injury (TBI) remains uncertain. We
hypothesize that cerebral metabolic crisis is frequent despite adequate resuscitation of the …

Head injury remains an important cause of death and disability in young adults. This review
will discuss the role of structural imaging using computed tomography (CT) and magnetic …