Pericontusional brain tissue exhibits persistent elevation of lactate/pyruvate ratio independent of cerebral perfusion pressure
Objective: To determine whether pericontusional tissue exhibits neurochemical
responsiveness to changes in cerebral perfusion pressure as measured by microdialysis …
responsiveness to changes in cerebral perfusion pressure as measured by microdialysis …
Glucose metabolism following human traumatic brain injury: methods of assessment and pathophysiological findings
The pathophysiology of traumatic brain (TBI) injury involves changes to glucose uptake into
the brain and its subsequent metabolism. We review the methods used to study cerebral …
the brain and its subsequent metabolism. We review the methods used to study cerebral …
Cerebral lactate metabolism after traumatic brain injury
C Patet, T Suys, L Carteron, M Oddo - Current neurology and neuroscience …, 2016 - Springer
Cerebral energy dysfunction has emerged as an important determinant of prognosis
following traumatic brain injury (TBI). A number of studies using cerebral microdialysis …
following traumatic brain injury (TBI). A number of studies using cerebral microdialysis …
Anemia and red blood cell transfusion in neurocritical care
AH Kramer, DA Zygun - Critical care, 2009 - Springer
Introduction Anemia is one of the most common medical complications to be encountered in
critically ill patients. Based on the results of clinical trials, transfusion practices across the …
critically ill patients. Based on the results of clinical trials, transfusion practices across the …
Metabolic failure precedes intracranial pressure rises in traumatic brain injury: a microdialysis study
Background: Cerebral microdialysis (MD) is able to detect markers of tissue damage and
cerebral ischaemia and can be used to monitor the biochemical changes subsequent to …
cerebral ischaemia and can be used to monitor the biochemical changes subsequent to …
Neuroprotection for traumatic brain injury
Traumatic brain injury (TBI) is a major cause of mortality and morbidity worldwide. Despite
extensive preclinical research supporting the effectiveness of neuroprotective therapies for …
extensive preclinical research supporting the effectiveness of neuroprotective therapies for …
Simultaneous multispectral reflectance imaging and laser speckle flowmetry of cerebral blood flow and oxygen metabolism in focal cerebral ischemia
PB Jones, HK Shin, DA Boas… - … of biomedical optics, 2008 - spiedigitallibrary.org
Real-time investigation of cerebral blood flow (CBF), and oxy-and deoxyhemoglobin
concentration (HbO, HbR) dynamics has been difficult until recently due to limited spatial …
concentration (HbO, HbR) dynamics has been difficult until recently due to limited spatial …
Shedding light on the adult brain: a review of the clinical applications of near-infrared spectroscopy
M Smith - … Transactions of the Royal Society A …, 2011 - royalsocietypublishing.org
Near-infrared spectroscopy (NIRS) has potential as a non-invasive brain monitor in a wide
range of clinical scenarios. In the last decade, there has been a rapid expansion of clinical …
range of clinical scenarios. In the last decade, there has been a rapid expansion of clinical …
Multimodal monitoring in traumatic brain injury: current status and future directions
MM Tisdall, M Smith - British journal of anaesthesia, 2007 - academic.oup.com
Traumatic brain injury (TBI) remains a major cause of morbidity and mortality, particularly in
young people. Despite encouraging animal studies, human trials assessing the use of …
young people. Despite encouraging animal studies, human trials assessing the use of …
Excitotoxicity and metabolic crisis are associated with spreading depolarizations in severe traumatic brain injury patients
Cerebral microdialysis has enabled the clinical characterization of excitotoxicity (glutamate>
10 μM) and non-ischemic metabolic crisis (lactate/pyruvate ratio [LPR]> 40) as important …
10 μM) and non-ischemic metabolic crisis (lactate/pyruvate ratio [LPR]> 40) as important …