Pyroptosis is an inflammatory form of programmed cell death that holds great promise in
cancer therapy. However, autophagy as the crucial pyroptosis checkpoint and the self …

SARS-CoV-2 causes acute respiratory distress that can progress to multiorgan failure and
death in a minority of patients. Although severe COVID-19 disease is linked to exuberant …

Immunogenic programmed cell death, such as pyroptosis and ferroptosis, efficiently induces
an acute inflammatory response and boosts antitumor immunity. However, the exploration of …

Macrophages infected with Gram-negative bacteria expressing Type III secretion system
(T3SS) activate the NLRC4 inflammasome, resulting in Gasdermin D (GSDMD)-dependent …

The molecular bases of how host genetic variation impacts the gut microbiome remain
largely unknown. Here we used a genetically diverse mouse population and applied …

Gasdermin D (GSDMD)-mediated pyroptosis and downstream inflammation are important
self-protection mechanisms against stimuli and infections. Hosts can defend against …

In the early 2000s, caspase-1, an important molecule that has been shown to be involved in
the regulation of inflammation, cell survival and diseases, was given a new function …

The accrual of cytosolic DNA leads to transcription of type I IFNs, proteolytic maturation of
the IL-1 family of cytokines, and pyroptotic cell death. Caspase-1 cleaves pro-IL1β to …

Stroke has caused tremendous social stress worldwide, yet despite decades of research
and development of new stroke drugs, most have failed and rt-PA (Recombinant tissue …

During atherosclerosis, lipid-rich plaques are formed in large-and medium-sized arteries,
which can reduce blood flow to tissues. This situation becomes particularly precarious when …