Prostate cancer exerts a greater toll on African American men than on White men of
European descent (hereafter referred to as European American men): the disparity in …

Since the proposition of the pro‐invasive activity of proteolytic enzymes over 70 years ago,
several roles for proteases in cancer progression have been established. About half of the …

Background Lynch syndrome is a rare familial cancer syndrome caused by pathogenic
variants in the mismatch repair genes MLH1, MSH2, MSH6, or PMS2, that cause …

Genome-wide association studies have identified 270 loci conferring risk for prostate cancer
(PCa), yet the underlying biology and clinical impact remain to be investigated. Here we …

Our understanding of stromal components, specifically cancer-associated fibroblasts (CAF),
in prostate cancer (PCa), has evolved from considering these cells as inert bystanders to …

Abstract Purpose of Review Prostate cancer (PrCa) is the most common cancer in men in
the western world and is a major source of morbidity and mortality. Currently, general …

Prostate cancer (PCa) is the second most common cancer in men and is a highly heritable
disease that affects millions of individuals worldwide. Genome-wide association studies …

Background Germline variants explain more than a third of prostate cancer (PrCa) risk, but
very few associations have been identified between heritable factors and clinical …

Importance Prostate cancer in Black men compared with White men may be more sensitive
to radiation therapy resulting in better outcomes in equal-access settings. The outcomes of …

Disparities in cancer incidence, prevalence, burden, and outcome exist among specific
population groups in the United States. Researchers have identified germline genetic risk …