Transactive response DNA binding protein of 43 kDa (TDP-43) is an intranuclear protein
encoded by the TARDBP gene that is involved in RNA splicing, trafficking, stabilization, and …

Frontotemporal dementia (FTD) is a neurodegenerative disease of growing interest, since it
accounts for up to 10% of middle-age-onset dementias and entails a social, economic, and …

Zygotic genome activation (ZGA) is essential for early embryonic development. However, the
regulation of ZGA remains elusive in mammals. Here we report that a maternal factor TDP …

Our understanding of amyotrophic lateral sclerosis and frontotemporal dementia has
advanced dramatically since the discovery of cytoplasmic TAR DNA-binding protein 43 (TDP …

Inter-cellular movement of “prion-like” proteins is thought to explain propagation of
neurodegeneration between cells. For example, propagation of abnormally phosphorylated …

In recent years, more and more neurodegenerative diseases, such as ALS, FTLD and AD,
have been found to share a common pathological feature, which is the depletion of TDP-43 …

The prevalence of neurodegenerative disease (ND) is increasing, partly owing to extensions
in lifespan, with a larger percentage of members living to an older age, but the ND aetiology …

Background Amyotrophic lateral sclerosis (ALS) associated with TAR DNA-binding protein
43 (TDP-43) aggregation has been considered as a lethal and progressive motor neuron …

Alzheimer's disease (AD) is the most common, age-dependent neurodegenerative disorder.
While AD has been intensively studied from different aspects, there is no effective cure for …

The transactive response DNA-binding protein-43 (TDP-43) is a multi-facet protein involved
in phase separation, RNA-binding, and alternative splicing. In the context of …