[HTML][HTML] RIG-I-like receptors: their regulation and roles in RNA sensing
J Rehwinkel, MU Gack - Nature Reviews Immunology, 2020 - nature.com
Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are key sensors of virus
infection, mediating the transcriptional induction of type I interferons and other genes that …
infection, mediating the transcriptional induction of type I interferons and other genes that …
Regulation of RIG-I-like receptor-mediated signaling: interaction between host and viral factors
K Onomoto, K Onoguchi, M Yoneyama - Cellular & molecular …, 2021 - nature.com
Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are RNA sensor molecules that
play essential roles in innate antiviral immunity. Among the three RLRs encoded by the …
play essential roles in innate antiviral immunity. Among the three RLRs encoded by the …
Pan-cancer characterization of immune-related lncRNAs identifies potential oncogenic biomarkers
Y Li, T Jiang, W Zhou, J Li, X Li, Q Wang, X Jin… - Nature …, 2020 - nature.com
Long noncoding RNAs (lncRNAs) are emerging as critical regulators of gene expression
and they play fundamental roles in immune regulation. Here we introduce an integrated …
and they play fundamental roles in immune regulation. Here we introduce an integrated …
Comparative structure and function analysis of the RIG-I-like receptors: RIG-I and MDA5
RIG-I (Retinoic acid-inducible gene I) and MDA5 (Melanoma Differentiation-Associated
protein 5), collectively known as the RIG-I-like receptors (RLRs), are key protein sensors of …
protein 5), collectively known as the RIG-I-like receptors (RLRs), are key protein sensors of …
A dual-role of SARS-CoV-2 nucleocapsid protein in regulating innate immune response
Y Zhao, L Sui, P Wu, W Wang, Z Wang, Y Yu… - … and Targeted Therapy, 2021 - nature.com
The recently emerged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),
which is the causative agent of ongoing global pandemic of COVID-19, may trigger …
which is the causative agent of ongoing global pandemic of COVID-19, may trigger …
Circular RNA EIF4G3 suppresses gastric cancer progression through inhibition of β-catenin by promoting δ-catenin ubiquitin degradation and upregulating SIK1
X Zang, J Jiang, J Gu, Y Chen, M Wang, Y Zhang… - Molecular Cancer, 2022 - Springer
Background Increasing studies suggest that circular RNAs (circRNAs) are critical regulators
of cancer development and progression. However, the biological roles and mechanisms of …
of cancer development and progression. However, the biological roles and mechanisms of …
Distinct and orchestrated functions of RNA sensors in innate immunity
Faithful maintenance of immune homeostasis relies on the capacity of the cellular immune
surveillance machinery to recognize" nonself", such as the presence of pathogenic RNA …
surveillance machinery to recognize" nonself", such as the presence of pathogenic RNA …
mRNA vaccine: a potential therapeutic strategy
Y Wang, Z Zhang, J Luo, X Han, Y Wei, X Wei - Molecular cancer, 2021 - Springer
Abstract mRNA vaccines have tremendous potential to fight against cancer and viral
diseases due to superiorities in safety, efficacy and industrial production. In recent decades …
diseases due to superiorities in safety, efficacy and industrial production. In recent decades …
Epigenetic remodeling in innate immunity and inflammation
Q Zhang, X Cao - Annual review of immunology, 2021 - annualreviews.org
The innate immune response is a rapid response to pathogens or danger signals. It is
precisely activated not only to efficiently eliminate pathogens but also to avoid excessive …
precisely activated not only to efficiently eliminate pathogens but also to avoid excessive …
LncRNA INHEG promotes glioma stem cell maintenance and tumorigenicity through regulating rRNA 2'-O-methylation
Glioblastoma (GBM) ranks among the most lethal of human cancers, containing glioma stem
cells (GSCs) that display therapeutic resistance. Here, we report that the lncRNA INHEG is …
cells (GSCs) that display therapeutic resistance. Here, we report that the lncRNA INHEG is …