Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are key sensors of virus
infection, mediating the transcriptional induction of type I interferons and other genes that …

Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are RNA sensor molecules that
play essential roles in innate antiviral immunity. Among the three RLRs encoded by the …

Long noncoding RNAs (lncRNAs) are emerging as critical regulators of gene expression
and they play fundamental roles in immune regulation. Here we introduce an integrated …

RIG-I (Retinoic acid-inducible gene I) and MDA5 (Melanoma Differentiation-Associated
protein 5), collectively known as the RIG-I-like receptors (RLRs), are key protein sensors of …

The recently emerged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),
which is the causative agent of ongoing global pandemic of COVID-19, may trigger …

Background Increasing studies suggest that circular RNAs (circRNAs) are critical regulators
of cancer development and progression. However, the biological roles and mechanisms of …

Faithful maintenance of immune homeostasis relies on the capacity of the cellular immune
surveillance machinery to recognize" nonself", such as the presence of pathogenic RNA …

Abstract mRNA vaccines have tremendous potential to fight against cancer and viral
diseases due to superiorities in safety, efficacy and industrial production. In recent decades …

The innate immune response is a rapid response to pathogens or danger signals. It is
precisely activated not only to efficiently eliminate pathogens but also to avoid excessive …

Glioblastoma (GBM) ranks among the most lethal of human cancers, containing glioma stem
cells (GSCs) that display therapeutic resistance. Here, we report that the lncRNA INHEG is …