The recently identified novel cytosolic DNA sensor cyclic GMP-AMP synthase (cGAS)
activates the downstream adaptor protein stimulator of interferon genes (STING) by …

Objective Autoinflammatory type I interferonopathies, chronic atypical neutrophilic
dermatosis with lipodystrophy and elevated temperature/proteasome-associated …

Stimulator of interferon genes (STING)-associated vasculopathy with onset in infancy (SAVI)
is a very rare autoinflammatory disease related to STING1 mutation. SAVI is mainly …

Numerous liver diseases, such as nonalcoholic fatty liver disease, hepatitis, hepatocellular
carcinoma, and hepatic ischemia-reperfusion injury, have been increasingly prevalent …

Dry eye is one of the most common ocular surface diseases in the world and seriously
affects the quality of life of patients. As an immune-related disease, the mechanism of dry …

Transplantation is an important life-saving therapeutic choice for patients with organ or
tissue failure once all other treatment options are exhausted. However, most allografts …

Background: Stimulator of interferon gene (STING)-associated vasculopathy with onset in
infancy (SAVI), caused by gain-of-function mutations in human transmembrane protein 173 …

Objective: Autoinflammatory type I interferonopathies, chronic atypical neutrophilic
dermatosis with lipodystrophy and elevated temperature/proteasome-associated …

Coatomer subunit alpha (COPA) syndrome is an autoinflammatory disease with
autoimmune and autoinflammatory manifestations affecting lungs, joints, and kidneys. COPA …

The article presents data from the scientific literature about the etiology, pathogenesis, and
clinical manifestations of a recently discovered disease-childhood-onset STING-associated …