Determining patient's coagulation profile, ie detecting a bleeding tendency or the opposite, a
thrombotic risk, is crucial for clinicians in many situations. Routine coagulation assays and …

Diagnosis of antiphospholipid syndrome (APS) requires the presence of a clinical criterion
(thrombosis and/or pregnancy morbidity), combined with persistently circulating …

Direct oral anticoagulants (DOACs) account for most oral anticoagulant use. DOAC-
associated bleeding events are commonly encountered in clinical practice and are …

Cardiovascular diseases (CVDs) are currently the leading cause of death worldwide.
Therefore, there is interest in the search for cardiovascular risk markers that contribute to the …

Direct oral anticoagulants against activated factor X and thrombin were the last milestone in
thrombosis treatment. Step by step, they replaced antivitamin K and heparins in most of their …

Treatment of bleeding and thrombotic disorders is highly standardized and based on
evidence-based medicine guidelines. These evidence-based treatment schemes are well …

Background Mim8 is a novel antifactor IXa/antifactor X bispecific antibody in clinical
development for prophylactic treatment of hemophilia A with and without inhibitors. Patients …

There is a lack of evidence-based reviews on the effects of laser irradiation on blood
coagulation in the literature, despite a large number of clinical trials. We therefore evaluated …

The blood coagulation cascade is a complex physiological process involving the action of
multiple coupled enzymes, cofactors, and substrates, ultimately leading to clot formation …

Thrombin plays an essential role in achieving and maintaining effective hemostasis and
stable clot formation. In people with hemophilia, deficiency of procoagulant factor (F) VIII or …