Gene–environment interactions in Alzheimer disease: the emerging role of epigenetics
L Migliore, F Coppedè - Nature Reviews Neurology, 2022 - nature.com
With the exception of a few monogenic forms, Alzheimer disease (AD) has a complex
aetiology that is likely to involve multiple susceptibility genes and environmental factors. The …
aetiology that is likely to involve multiple susceptibility genes and environmental factors. The …
[HTML][HTML] Present and future challenges for the investigation of transgenerational epigenetic inheritance
Epigenetic pathways are essential in different biological processes and in phenotype-
environment interactions in response to different stressors and they can induce phenotypic …
environment interactions in response to different stressors and they can induce phenotypic …
The molecular mechanisms of adaptive response related to environmental stress
A Rossnerova, A Izzotti, A Pulliero, A Bast… - International journal of …, 2020 - mdpi.com
The exposure of living organisms to environmental stress triggers defensive responses
resulting in the activation of protective processes. Whenever the exposure occurs at low …
resulting in the activation of protective processes. Whenever the exposure occurs at low …
The exposome and toxicology: a win–win collaboration
R Barouki, K Audouze, C Becker, L Blaha… - Toxicological …, 2022 - academic.oup.com
The development of the exposome concept has been one of the hallmarks of environmental
and health research for the last decade. The exposome encompasses the life course …
and health research for the last decade. The exposome encompasses the life course …
METTL3-mediated m6A mRNA modification was involved in cadmium-induced liver injury
W Li, M Tan, H Wang, Z Wang, Y Pang, R Yang… - Environmental …, 2023 - Elsevier
Cadmium is an environmental pollutant that has extensive deleterious effects. However, the
mechanisms underlying the hepatotoxicity induced by long-term exposure to cadmium …
mechanisms underlying the hepatotoxicity induced by long-term exposure to cadmium …
[HTML][HTML] Ecotoxicological epigenetics in invertebrates: Emerging tool for the evaluation of present and past pollution burden
M Šrut - Chemosphere, 2021 - Elsevier
The effect of environmental pollution on epigenetic changes and their heredity in affected
organisms is of major concern as such changes can play a significant role in adaptation to …
organisms is of major concern as such changes can play a significant role in adaptation to …
[HTML][HTML] Biomarkers of effect as determined in human biomonitoring studies on hexavalent chromium and cadmium in the period 2008–2020
A number of human biomonitoring (HBM) studies have presented data on exposure to
hexavalent chromium [Cr (VI)] and cadmium (Cd), but comparatively few include results on …
hexavalent chromium [Cr (VI)] and cadmium (Cd), but comparatively few include results on …
Perspectives on the use of toxicogenomics to assess environmental risk
J Portugal, S Mansilla, B Piña - Frontiers in bioscience (Landmark …, 2022 - digital.csic.es
Environmental toxicogenomics aims to collect, analyze and interpret data on changes in
gene expression and protein activity resulting from exposure to toxic substances using high …
gene expression and protein activity resulting from exposure to toxic substances using high …
Epigenetic alteration shaped by the environmental chemical bisphenol A
T Qin, X Zhang, T Guo, T Yang, Y Gao, W Hao… - Frontiers in …, 2021 - frontiersin.org
Bisphenol A (BPA) is extensively used in plastic products and epoxy resins. The epigenetic
response to the environmental chemical BPA was involved in multiple dysfunctional …
response to the environmental chemical BPA was involved in multiple dysfunctional …
Integration of epigenetic mechanisms into non-genotoxic carcinogenicity hazard assessment: Focus on DNA methylation and histone modifications
D Desaulniers, P Vasseur, A Jacobs… - International Journal of …, 2021 - mdpi.com
Epigenetics involves a series of mechanisms that entail histone and DNA covalent
modifications and non-coding RNAs, and that collectively contribute to programing cell …
modifications and non-coding RNAs, and that collectively contribute to programing cell …