Objective To review the published literature regarding the effects of anesthesia on cancer
surgery to prevent tumor cell proliferation/migration or induce apoptosis. Background …

Purpose Pain commonly occurs in cancer patients, and has been associated with shorter
survival. However, the importance of pain is less clear when analyzed with other known …

Recent epidemiologic studies implying differences in cancer recurrence based on
anesthetic regimens raise the possibility that the mu opioid receptor (MOR) can influence …

Background We and others have previously demonstrated that the μ-opioid receptor (MOR)
is overexpressed in several human malignancies. There is a seven-fold increase in MOR in …

Background Opioid-induced immunomodulation may be of particular importance in triple-
negative breast cancer (TNBC) where an immune response is associated with improved …

Preclinical studies have demonstrated that opioid receptor agonists increase the rate of non‐
small cell lung cancer (NSCLC) growth and metastasis. Following institutional review board …

Background Methylnaltrexone (MNTX), a peripherally acting μ-opioid receptor (MOR)
antagonist, is FDA-approved for treatment of opioid-induced constipation (OIC). Preclinical …

This study aimed to investigate the risk of death, development of cancer, and hospital
inpatient admissions resulting from injuries and toxicity/poisoning among opioid users with …

Background Pain is associated with shorter survival in non-small cell lung cancer (NSCLC).
Lung cancer cells express opioid receptors. Opioids promote angiogenesis, tumour growth …

Mu opioids are among the most widely used drugs for patients with cancer with both acute
and chronic pain as well as in the perioperative period. Several retrospective studies have …