Epidermal growth factor receptor inhibitors as potential anticancer agents: An update of recent progress
Epidermal growth factor receptor (EGFR) is a vital intermediate in cell signaling pathway
including cell proliferation, angiogenesis, apoptosis, and metastatic spread and also having …
including cell proliferation, angiogenesis, apoptosis, and metastatic spread and also having …
[HTML][HTML] Substituted pyrazoles and their heteroannulated analogs—recent syntheses and biological activities
Pyrazoles are considered privileged scaffolds in medicinal chemistry. Previous reviews have
discussed the importance of pyrazoles and their biological activities; however, few have …
discussed the importance of pyrazoles and their biological activities; however, few have …
Optimization and SAR investigation of novel 2, 3-dihydropyrazino [1, 2-a] indole-1, 4-dione derivatives as EGFR and BRAFV600E dual inhibitors with potent …
Using a single drug to treat cancer with dual-targeting is an unusual approach when
compared to other drug combinations. Dual-targeting agents were developed as a result of …
compared to other drug combinations. Dual-targeting agents were developed as a result of …
Design, synthesis, and biological evaluation of novel EGFR inhibitors containing 5-chloro-3-hydroxymethyl-indole-2-carboxamide scaffold with apoptotic …
New EGFR inhibitor series of fifteen 5-chloro-3-hydroxymethyl-indole-2-carboxamide
derivatives has been designed, synthesized, and tested for antiproliferative activity against a …
derivatives has been designed, synthesized, and tested for antiproliferative activity against a …
Design and synthesis of new triarylimidazole derivatives as dual inhibitors of BRAFV600E/p38α with potential antiproliferative activity
Recent studies have shown that combining kinase inhibitors has additive and synergistic
effects. BRAF V600E and p38α have been extensively studied as potential therapeutic …
effects. BRAF V600E and p38α have been extensively studied as potential therapeutic …
Structure-based design, synthesis and antiproliferative action of new quinazoline-4-one/chalcone hybrids as EGFR inhibitors
A new series of quinazoline-4-one/chalcone hybrids, 7–26, was synthesized in this study as
EGFR inhibitors with antiproliferative activity. Target compounds were synthesized and in …
EGFR inhibitors with antiproliferative activity. Target compounds were synthesized and in …
Novel 4-(piperazin-1-yl) quinolin-2 (1H)-one bearing thiazoles with antiproliferative activity through VEGFR-2-TK inhibition
Abstract A new series of 2-(4-(2-oxo-1, 2-dihydroquinolin-4-yl) piperazin-1-yl)-N-(4-
phenylthiazol-2-yl) acetamide derivatives were synthesized and evaluated for anticancer …
phenylthiazol-2-yl) acetamide derivatives were synthesized and evaluated for anticancer …
Synthesis and biological assessment of indole derivatives containing penta-heterocycles scaffold as novel anticancer agents towards A549 and K562 cells
G Zhang, Z Tang, S Fan, C Li, Y Li, W Liu… - Journal of Enzyme …, 2023 - Taylor & Francis
Herein, a new series of 2-chloro-N-(5-(2-oxoindolin-3-yl)-4 H-pyrazol-3-yl) acetamide
derivatives containing 1, 3, 4-thiadiazole (10a–i) and 4 H-1, 2, 4-triazol-4-amine (11a–r) …
derivatives containing 1, 3, 4-thiadiazole (10a–i) and 4 H-1, 2, 4-triazol-4-amine (11a–r) …
[HTML][HTML] Novel 1, 2, 4-oxadiazole/pyrrolidine hybrids as DNA gyrase and topoisomerase IV inhibitors with potential antibacterial activity
FOA Frejat, Y Cao, H Zhai, SA Abdel-Aziz… - Arabian Journal of …, 2022 - Elsevier
DNA gyrase is a promising target for antibacterial agents. Several classes of small-molecule
inhibitors have been discovered in recent decades, but none of these have reached the …
inhibitors have been discovered in recent decades, but none of these have reached the …
Quinolones as prospective drugs: Their syntheses and biological applications
Quinolones continue to receive significant attention owing to their diverse range of biological
activities. They provide an important scaffold in anticancer, antibacterial and antiviral drug …
activities. They provide an important scaffold in anticancer, antibacterial and antiviral drug …