Cognitive impairment in multiple sclerosis

K Maiese - Bioengineering, 2023 - mdpi.com
Almost three million individuals suffer from multiple sclerosis (MS) throughout the world, a
demyelinating disease in the nervous system with increased prevalence over the last five …

The impact of aging and oxidative stress in metabolic and nervous system disorders: programmed cell death and molecular signal transduction crosstalk

K Maiese - Frontiers in immunology, 2023 - frontiersin.org
Life expectancy is increasing throughout the world and coincides with a rise in non-
communicable diseases (NCDs), especially for metabolic disease that includes diabetes …

SIRT1 activation promotes energy homeostasis and reprograms liver cancer metabolism

B Varghese, U Chianese, L Capasso, V Sian… - Journal of Translational …, 2023 - Springer
Background Cancer cells are characterized by uncontrolled cell proliferation and impaired
bioenergetics. Sirtuins are a family of highly conserved enzymes that play a fundamental …

Activation of the sirtuin silent information regulator 1 pathway inhibits pathological myocardial remodeling

Y Wang, R Zhao, C Wu, X Liang, L He… - Frontiers in …, 2023 - frontiersin.org
Myocardial remodeling refers to structural and functional disorders of the heart caused by
molecular biological changes in the cardiac myocytes in response to neurological and …

Cornerstone Cellular pathways for metabolic disorders and Diabetes Mellitus: non-coding RNAs, wnt signaling, and AMPK

K Maiese - Cells, 2023 - mdpi.com
Metabolic disorders and diabetes (DM) impact more than five hundred million individuals
throughout the world and are insidious in onset, chronic in nature, and yield significant …

Cold Exposure Induces Intestinal Barrier Damage and Endoplasmic Reticulum Stress in the Colon via the SIRT1/Nrf2 Signaling Pathway

J Guo, H Hu, Z Chen, J Xu, J Nie, J Lu, L Ma… - Frontiers in …, 2022 - frontiersin.org
Ambient air temperature is a key factor affecting human health. Long-term exposure to a cold
environment can cause various diseases, while the impact on the intestine, the organ which …

GPER activation attenuates cardiac dysfunction by upregulating the SIRT1/3-AMPK-UCP2 pathway in postmenopausal diabetic rats

H Azizian, Z Farhadi, M Bader, J Alizadeh Ghalenoei… - Plos one, 2023 - journals.plos.org
Postmenopausal diabetic women are at higher risk to develop cardiovascular diseases
(CVD) compared with nondiabetic women. Alterations in cardiac cellular metabolism caused …

Beneficial and sexually dimorphic response to combined HDAC inhibitor valproate and AMPK/SIRT1 pathway activator resveratrol in the treatment of ALS mice

O Bankole, I Scambi, E Parrella, M Muccilli… - International Journal of …, 2022 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is a fatal adult-onset neurodegenerative disorder. There
is no cure and current treatments fail to slow the progression of the disease. Epigenetic …

Novel Indoline Spiropyrans Based on Human Hormones β-Estradiol and Estrone: Synthesis, Structure, Chromogenic and Cytotoxic Properties

IV Ozhogin, AD Pugachev, NI Makarova, AA Belanova… - Molecules, 2023 - mdpi.com
The introduction of a switchable function into the structure of a bioactive compound can
endow it with unique capabilities for regulating biological activity under the influence of …

Anti-heart failure mechanism of saponin extract of black ginseng based on metabolomics

T Dai, F Yan, J Gong, S Liu - Journal of Pharmaceutical and Biomedical …, 2023 - Elsevier
Objective This study aimed to explore the mechanism of total saponin of black ginseng
(TSBG) in treating heart failure (HF) in DOX-induced HF model rats. Methods Rats with HF …