Cancer stem cells (CSC) possess abilities generally associated with embryonic or adult
stem cells, especially self-renewal and differentiation. The CSC model assumes that this …

Abstract The Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades are often activated by
genetic alterations in upstream signaling molecules such as receptor tyrosine kinases …

Whether cancer is maintained by a small number of stem cells or is composed of
proliferating cells with approximate phenotypic equivalency is a central question in cancer …

Chronic myeloid leukemia (CML) is a clonal myeloproliferative neoplasm driven by BCR-
ABL1 oncoprotein, which plays a pivotal role in CML pathology, diagnosis, and treatment as …

Cancer stem cells (CSC) possess abilities generally associated with embryonic or adult
stem cells, especially self-renewal and differentiation, but also dormancy and cellular …

The hedgehog (Hh) pathway is aberrantly activated in a number of tumors. In
medulloblastoma, basal cell carcinoma, and rhabdomyosarcoma, mutations in Hh pathway …

Leukemia stem cells (LSCs) play a pivotal role in the resistance of chronic myeloid leukemia
(CML) to tyrosine kinase inhibitors (TKIs) and its progression to blast crisis (BC), in part …

Acute myeloid leukemia (AML) is a life-threatening stem cell disease characterized by
uncontrolled proliferation and accumulation of myeloblasts. Using an advanced RNAi …

Chronic myeloid leukemia (CML) patients in sustained “deep molecular response” may stop
TKI treatment without disease recurrence; however, half of them lose molecular response …

Chronic myeloid leukemia (CML) is caused by formation of the BCR–ABL1 fusion protein.
Tyrosine kinase inhibitors (TKI) that target BCR–ABL1 are now the standard of care for …