Is oxytocin “nature's medicine”?

CS Carter, WM Kenkel, EL MacLean, SR Wilson… - Pharmacological …, 2020 - ASPET
Oxytocin is a pleiotropic, peptide hormone with broad implications for general health,
adaptation, development, reproduction, and social behavior. Endogenous oxytocin and …

Oxytocin, vasopressin, and social behavior: from neural circuits to clinical opportunities

N Rigney, GJ de Vries, A Petrulis, LJ Young - Endocrinology, 2022 - academic.oup.com
Oxytocin and vasopressin are peptide hormones secreted from the pituitary that are well
known for their peripheral endocrine effects on childbirth/nursing and blood pressure/urine …

Rescue of oxytocin response and social behaviour in a mouse model of autism

H Hörnberg, E Pérez-Garci, D Schreiner… - Nature, 2020 - nature.com
A fundamental challenge in developing treatments for autism spectrum disorders is the
heterogeneity of the condition. More than one hundred genetic mutations confer high risk for …

Top-down regulation of motivated behaviors via lateral septum sub-circuits

A Besnard, F Leroy - Molecular psychiatry, 2022 - nature.com
How does cognition regulate innate behaviors? While the cognitive functions of the cortex
have been extensively studied, we know much less about how cognition can regulate innate …

Oxytocin and vasopressin within the ventral and dorsal lateral septum modulate aggression in female rats

VEM Oliveira, M Lukas, HN Wolf, E Durante… - Nature …, 2021 - nature.com
In contrast to male rats, aggression in virgin female rats has been rarely studied. Here, we
established a rat model of enhanced aggression in females using a combination of social …

Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery

Z Song, HE Albers - Frontiers in neuroendocrinology, 2018 - Elsevier
Oxytocin (OT) and arginine-vasopressin (AVP) act in the brain to regulate social
cognition/social behavior and in the periphery to influence a variety of physiological …

The oxytocin–vasopressin pathway in the context of love and fear

CS Carter - Frontiers in endocrinology, 2017 - frontiersin.org
Vasopressin (VP) and oxytocin (OT) are distinct molecules; these peptides and their
receptors [OT receptor (OTR) and V1a receptor (V1aR)] also are evolved components of an …

Extrahypothalamic oxytocin neurons drive stress-induced social vigilance and avoidance

N Duque-Wilckens, LY Torres… - Proceedings of the …, 2020 - National Acad Sciences
Oxytocin increases the salience of both positive and negative social contexts and it is
thought that these diverse actions on behavior are mediated in part through circuit-specific …

Oxytocin receptors in the anteromedial bed nucleus of the stria terminalis promote stress-induced social avoidance in female California mice

N Duque-Wilckens, MQ Steinman, M Busnelli… - Biological …, 2018 - Elsevier
Background The neuropeptide oxytocin (OT) is a key regulator of social and emotional
behaviors. The effects of OT are context dependent, and it has been proposed that OT …

Sex differences in the regulation of social and anxiety-related behaviors: insights from vasopressin and oxytocin brain systems

R Bredewold, AH Veenema - Current opinion in neurobiology, 2018 - Elsevier
Highlights•AVP regulates social behavior and anxiety in sex-specific ways in juvenile
rats.•OXT induces sex-specific activation of same three brain regions in humans and …