Genetics and neurobiology of eating disorders
Eating disorders (anorexia nervosa, bulimia nervosa and binge-eating disorder) are a
heterogeneous class of complex illnesses marked by weight and appetite dysregulation …
heterogeneous class of complex illnesses marked by weight and appetite dysregulation …
The role of hypoleptinemia in the psychological and behavioral adaptation to starvation: Implications for anorexia nervosa
J Hebebrand, T Hildebrandt, H Schlögl, J Seitz… - Neuroscience & …, 2022 - Elsevier
This narrative review aims to pinpoint mental and behavioral effects of starvation, which may
be triggered by hypoleptinemia and as such may be amenable to treatment with leptin …
be triggered by hypoleptinemia and as such may be amenable to treatment with leptin …
A D2 to D1 shift in dopaminergic inputs to midbrain 5-HT neurons causes anorexia in mice
Midbrain dopamine (DA) and serotonin (5-HT) neurons regulate motivated behaviors,
including feeding, but less is known about how these circuits may interact. In this study, we …
including feeding, but less is known about how these circuits may interact. In this study, we …
[HTML][HTML] Animal models for anorexia nervosa—a systematic review
S Scharner, A Stengel - Frontiers in Human Neuroscience, 2021 - frontiersin.org
Anorexia nervosa is an eating disorder characterized by intense fear of gaining weight and a
distorted body image which usually leads to low caloric intake and hyperactivity. The …
distorted body image which usually leads to low caloric intake and hyperactivity. The …
How changes in dopamine D2 receptor levels alter striatal circuit function and motivation
It was first posited, more than five decades ago, that the etiology of schizophrenia involves
overstimulation of dopamine receptors. Since then, advanced clinical research methods …
overstimulation of dopamine receptors. Since then, advanced clinical research methods …
[HTML][HTML] GPCR-based dopamine sensors—a detailed guide to inform sensor choice for in vivo imaging
MA Labouesse, RB Cola, T Patriarchi - International journal of molecular …, 2020 - mdpi.com
Understanding how dopamine (DA) encodes behavior depends on technologies that can
reliably monitor DA release in freely-behaving animals. Recently, red and green genetically …
reliably monitor DA release in freely-behaving animals. Recently, red and green genetically …
[HTML][HTML] Activity-based anorexia animal model: a review of the main neurobiological findings
Background The genesis of anorexia nervosa (AN), a severe eating disorder with a
pervasive effect on many brain functions such as attention, emotions, reward processing …
pervasive effect on many brain functions such as attention, emotions, reward processing …
Shenling Baizhu San ameliorates non-alcoholic fatty liver disease in mice by modulating gut microbiota and metabolites
D Chen, Y Wang, J Yang, W Ou, G Lin… - Frontiers in …, 2024 - frontiersin.org
Purpose: The prevalence of non-alcoholic fatty liver disease (NAFLD) and its related
mortality is increasing at an unprecedented rate. Traditional Chinese medicine (TCM) has …
mortality is increasing at an unprecedented rate. Traditional Chinese medicine (TCM) has …
AgRP neurons coordinate the mitigation of activity-based anorexia
AK Sutton Hickey, SC Duane, LE Mickelsen… - Molecular …, 2023 - nature.com
Anorexia nervosa (AN) is a debilitating and deadly disease characterized by low body mass
index due to diminished food intake, and oftentimes concurrent hyperactivity. A high …
index due to diminished food intake, and oftentimes concurrent hyperactivity. A high …
[HTML][HTML] The rise and fall of dopamine: a two-stage model of the development and entrenchment of anorexia nervosa
JA Beeler, NS Burghardt - Frontiers in psychiatry, 2022 - frontiersin.org
Dopamine has long been implicated as a critical neural substrate mediating anorexia
nervosa (AN). Despite nearly 50 years of research, the putative direction of change in …
nervosa (AN). Despite nearly 50 years of research, the putative direction of change in …