The immunology of atopic dermatitis and its reversibility with broad-spectrum and targeted therapies

PM Brunner, E Guttman-Yassky, DYM Leung - Journal of Allergy and …, 2017 - Elsevier
Atopic dermatitis (AD), the most common chronic inflammatory skin disease, is driven by
both terminal keratinocyte differentiation defects and strong type 2 immune responses. In …

[HTML][HTML] Type 2 inflammation contributes to skin barrier dysfunction in atopic dermatitis

LA Beck, MJ Cork, M Amagai, A De Benedetto… - JID Innovations, 2022 - Elsevier
Skin barrier dysfunction, a defining feature of atopic dermatitis (AD), arises from multiple
interacting systems. In AD, skin inflammation is caused by host–environment interactions …

Immunologic, microbial, and epithelial interactions in atopic dermatitis

PM Brunner, DYM Leung, E Guttman-Yassky - Annals of Allergy, Asthma & …, 2018 - Elsevier
Objective To provide an overview of studies contributing to the understanding of
immunologic, microbial, and epithelial interactions in atopic dermatitis. Data Sources …

New treatments for atopic dermatitis targeting beyond IL-4/IL-13 cytokines

Y Renert-Yuval, E Guttman-Yassky - Annals of Allergy, Asthma & …, 2020 - Elsevier
Objective Atopic dermatitis (AD) is an increasingly common inflammatory skin disease
undergoing significant revolution in recent years. New data on disease pathogenesis …

Atopic dermatitis: new insight into the etiology, pathogenesis, diagnosis and novel treatment strategies

DS Mandlik, SK Mandlik - Immunopharmacology and …, 2021 - Taylor & Francis
Atopic dermatitis (AD) is the long-lasting chronic inflammatory skin condition associated with
cutaneous hyper-reactivity and triggered by environmental factors. The attributes of AD …

Histamine receptors and cancer pharmacology: an update

NA Massari, MB Nicoud… - British journal of …, 2020 - Wiley Online Library
In the present review, we will discuss the recent advances in the understanding of the role of
histamine and histamine receptors in cancer biology. The controversial role of the …

What's new in atopic dermatitis

Y Renert-Yuval, E Guttman-Yassky - Dermatologic clinics, 2019 - derm.theclinics.com
Atopic dermatitis (AD), perhaps the most common inflammatory skin disease, with an
increasing prevalence worldwide, is characterized by chronic symptoms of eczema and …

[HTML][HTML] Role of marine bacterial contaminants in histamine formation in seafood products: A review

AF Oktariani, Y Ramona, PE Sudaryatma, IAMM Dewi… - Microorganisms, 2022 - mdpi.com
Histamine is a toxic biogenic amine commonly found in seafood products or their
derivatives. This metabolite is produced by histamine-producing bacteria (HPB) such as …

High-affinity chemotaxis to histamine mediated by the TlpQ chemoreceptor of the human pathogen Pseudomonas aeruginosa

A Corral-Lugo, MA Matilla, D Martín-Mora… - MBio, 2018 - Am Soc Microbiol
Histamine is a key biological signaling molecule. It acts as a neurotransmitter in the central
and peripheral nervous systems and coordinates local inflammatory responses by …

[HTML][HTML] Differential expression and function of bicellular tight junctions in skin and oral wound healing

TR Leonardo, J Shi, D Chen, HM Trivedi… - International journal of …, 2020 - mdpi.com
Bicellular tight junctions are multiprotein complexes that are required for maintenance of
barrier function and fence function in epithelial tissues. Wound healing in the oral cavity …