Harnessing cytokines and chemokines for cancer therapy
DJ Propper, FR Balkwill - Nature reviews Clinical oncology, 2022 - nature.com
During the past 40 years, cytokines and cytokine receptors have been extensively
investigated as either cancer targets or cancer treatments. A strong preclinical rationale …
investigated as either cancer targets or cancer treatments. A strong preclinical rationale …
[HTML][HTML] The tumor microenvironment in tumorigenesis and therapy resistance revisited
Simple Summary Tumors are not masses of cancer cells alone but made up of cancer cells,
other cells including fibroblasts, macrophages, endothelial cells, as well as secreted factors …
other cells including fibroblasts, macrophages, endothelial cells, as well as secreted factors …
[HTML][HTML] The cytokine network in colorectal cancer: Implications for new treatment strategies
H Braumüller, B Mauerer, J Andris, C Berlin, T Wieder… - Cells, 2022 - mdpi.com
Colorectal cancer (CRC) is one of the most frequent tumor entities worldwide with only
limited therapeutic options. CRC is not only a genetic disease with several mutations in …
limited therapeutic options. CRC is not only a genetic disease with several mutations in …
[HTML][HTML] Cancer resistance to immunotherapy: comprehensive insights with future perspectives
SS Said, WN Ibrahim - Pharmaceutics, 2023 - mdpi.com
Cancer immunotherapy is a type of treatment that harnesses the power of the immune
systems of patients to target cancer cells with better precision compared to traditional …
systems of patients to target cancer cells with better precision compared to traditional …
Local scaffold-assisted delivery of immunotherapeutic agents for improved cancer immunotherapy
Q Shang, Y Dong, Y Su, F Leslie, M Sun… - Advanced Drug Delivery …, 2022 - Elsevier
Cancer immunotherapy, which reprograms a patient's own immune system to eradicate
cancer cells, has been demonstrated as a promising therapeutic strategy clinically. Immune …
cancer cells, has been demonstrated as a promising therapeutic strategy clinically. Immune …
Multifaceted role of chemokines in solid tumors: From biology to therapy
S Raza, S Rajak, A Tewari, P Gupta… - Seminars in cancer …, 2022 - Elsevier
Chemokines are small secretory chemotactic cytokines that control the directed migration of
immune cells. Chemokines are involved in both anti-and pro-tumorigenic immune …
immune cells. Chemokines are involved in both anti-and pro-tumorigenic immune …
[HTML][HTML] A novel T-cell exhaustion-related feature can accurately predict the prognosis of OC patients
K Yuan, S Zhao, B Ye, Q Wang, Y Liu… - Frontiers in …, 2023 - frontiersin.org
The phenomenon of T Cell exhaustion (TEX) entails a progressive deterioration in the
functionality of T cells within the immune system during prolonged conflicts with chronic …
functionality of T cells within the immune system during prolonged conflicts with chronic …
[HTML][HTML] Cancer stem cells and the tumor microenvironment: targeting the critical crosstalk through nanocarrier systems
A Nayak, NM Warrier, P Kumar - Stem cell reviews and reports, 2022 - Springer
The physiological state of the tumor microenvironment (TME) plays a central role in cancer
development due to multiple universal features that transcend heterogeneity and niche …
development due to multiple universal features that transcend heterogeneity and niche …
[HTML][HTML] Epigenetic reprogramming of Runx3 reinforces CD8+ T-cell function and improves the clinical response to immunotherapy
Z Liu, X Li, Y Gao, J Liu, Y Feng, Y Liu, J Wang… - Molecular Cancer, 2023 - Springer
Background Checkpoint blockade immunotherapy, represented by PD-1 or PD-L1 antibody
treatment, has been of tremendous success in clinical practice. However, the low clinical …
treatment, has been of tremendous success in clinical practice. However, the low clinical …
Role of the CXCR6/CXCL16 axis in autoimmune diseases
N Bao, B Fu, X Zhong, S Jia, Z Ren, H Wang… - International …, 2023 - Elsevier
Abstract The C–X–C motif ligand 16, or CXCL16, is a chemokine that belongs to the ELR−
CXC subfamily. Its function is to bind to the chemokine receptor CXCR6, which is a G protein …
CXC subfamily. Its function is to bind to the chemokine receptor CXCR6, which is a G protein …