Recent strategies and advances in the fabrication of nano lipid carriers and their application towards brain targeting

M Agrawal, S Saraf, S Saraf, SK Dubey, A Puri… - Journal of Controlled …, 2020 - Elsevier
In last two decades, the lipid nanocarriers have been extensively investigated for their drug
targeting efficiency towards the critical areas of the human body like CNS, cardiac region …

[HTML][HTML] The application of multifunctional nanomaterials in Alzheimer's disease: A potential theranostics strategy

Y Xu, M Zhao, D Zhou, T Zheng, H Zhang - Biomedicine & …, 2021 - Elsevier
By virtue of their small size, nanomaterials can cross the blood-brain barrier and, when
modified to target specific cells or regions, can achieve high bioavailability at the intended …

Nanotargeting of drug (s) for delaying dementia: relevance of covid-19 impact on dementia

JS D'Arrigo - American Journal of Alzheimer's Disease & …, 2020 - journals.sagepub.com
By incorporating appropriate drug (s) into lipid (biobased) nanocarriers, one obtains a
combination therapeutic for dementia treatment that targets certain cell-surface scavenger …

[HTML][HTML] Biomimetic nanocarrier targeting drug (s) to upstream-receptor mechanisms in dementia: focusing on linking pathogenic cascades

JS D'Arrigo - Biomimetics, 2020 - mdpi.com
Past published studies have already documented that, subsequent to the intravenous
injection of colloidal lipid nanocarriers, apolipoprotein (apo) AI is adsorbed from the blood …

[HTML][HTML] Alzheimer's disease, brain injury, and CNS nanotherapy in humans: Sonoporation augmenting drug targeting

JS D'Arrigo - Medical Sciences, 2017 - mdpi.com
Owing to the complexity of neurodegenerative diseases, multiple cellular types need to be
targeted simultaneously in order for a given therapy to demonstrate any major effectiveness …

[HTML][HTML] Arterial elasticity: Linking of cardiovascular risks, pulse pressure, dementia, aging, and drug targeting

J D'Arrigo - OBM Neurobiology, 2022 - lidsen.com
Cerebrovascular atherosclerosis, and several other cardiovascular (or" inflamm-aging" type)
diseases, are more frequent and advanced in subjects with Alzheimer's disease compared …

[HTML][HTML] Targeting Early Dementia: Using Lipid Cubic Phase Nanocarriers to Cross the Blood–Brain Barrier

JS D'Arrigo - Biomimetics, 2018 - mdpi.com
Over the past decades, a frequent co-morbidity of cerebrovascular pathology and
Alzheimer's disease has been observed. Numerous published studies indicate that the …

Microbubble based sonoporation—from the basics into clinical implications

P Wawryka, A Kiełbik, G Iwanek - Medical Research Journal, 2019 - journals.viamedica.pl
Sonoporation is a rapidly developing novel technique serving for drug delivery and non-viral
gene therapy. It is based on the interaction between microbubbles located in the …

[HTML][HTML] Pathophysiological linkage between aging and cognitive decline: implications for dementia treatment

J D'Arrigo - OBM Integrative and Complementary Medicine, 2022 - lidsen.com
The cardiovascular risk factors for dementia trigger widespread inflammation and oxidative
stress. These two interacting processes lead to neurodegeneration, gradual …

Network Pharmacology and molecular docking approach to unveil the mechanism of Hypericum perforatum in the management of Alzheimer's disorder

V Dogra, M Choudhary, A Parashar, N Choudhary - bioRxiv, 2023 - biorxiv.org
The pathogenesis of Alzheimer's disease (AD) is not fully understood which limits the
availability of safer and more efficient therapeutic strategies for the management of AD …