The view that substance addiction is a brain disease, although widely accepted in the
neuroscience community, has become subject to acerbic criticism in recent years. These …

Opioid use disorder (OUD) is a chronic relapsing disorder that, whilst initially driven by
activation of brain reward neurocircuits, increasingly engages anti-reward neurocircuits that …

The current opioid epidemic is one of the most severe public health crisis in US history.
Responding to it has been difficult due to its rapidly changing nature and the severity of its …

Opioid use disorder is characterised by the persistent use of opioids despite the adverse
consequences of its use. The disorder is associated with a range of mental and general …

Background People who inject drugs (PWID) encounter varying forms of stigma in health
services contexts, which can contribute to adverse outcomes. We explored the lived …

Background Retention in opioid substitution (OST) treatment is associated with substantial
reductions in all cause and overdose mortality. This systematic review aims to identify both …

Importance Opioid overdose deaths in the United States continue to increase, reflecting a
growing need to treat those with opioid use disorder (OUD). Little is known about counties …

Background Opioid-related deaths have risen dramatically in rural communities. Prior
studies highlight few medication treatment providers for opioid use disorder in rural …

At least 2.3 million people in the US have an opioid use disorder, less than 40% of whom
receive evidence-based treatment. Buprenorphine used as part of medication-assisted …

Drug use represents a significant burden to public health through disease, disability and
social problems, and policy makers are becoming increasingly interested in how to develop …