The multidimensional role of the Wnt/β‐catenin signaling pathway in human malignancies

IS Hiremath, A Goel, S Warrier… - Journal of Cellular …, 2022 - Wiley Online Library
Several signaling pathways have been identified as important for developmental processes.
One of such important cascades is the Wnt/β‐catenin signaling pathway, which can regulate …

[HTML][HTML] Hesperidin and its aglycone hesperetin in breast cancer therapy: A review of recent developments and future prospects

KM Yap, M Sekar, YS Wu, SH Gan, NNIM Rani… - Saudi Journal of …, 2021 - Elsevier
Breast cancer (BC) has high incidence and mortality rates, making it a major global health
issue. BC treatment has been challenging due to the presence of drug resistance and the …

Palmitic acid inhibits prostate cancer cell proliferation and metastasis by suppressing the PI3K/Akt pathway

S Zhu, W Jiao, Y Xu, L Hou, H Li, J Shao, X Zhang… - Life Sciences, 2021 - Elsevier
Aims Prostate cancer is one of the most frequent causes of cancer death in men worldwide,
and novel drugs for prostate cancer therapies are still being developed. Palmitic acid is a …

Bufotalin induces ferroptosis in non-small cell lung cancer cells by facilitating the ubiquitination and degradation of GPX4

W Zhang, B Jiang, Y Liu, L Xu, M Wan - Free Radical Biology and Medicine, 2022 - Elsevier
Ferroptosis is a new form of regulated cell death that is dependent on iron-and lipid reactive
oxygen species. Emerging evidence indicate that induction of ferroptosis could inhibit the …

Targeted delivery of curcumin in breast cancer cells via hyaluronic acid modified mesoporous silica nanoparticle to enhance anticancer efficiency

S Ghosh, S Dutta, A Sarkar, M Kundu, PC Sil - Colloids and Surfaces B …, 2021 - Elsevier
Curcumin (C) is a natural antioxidant which has many beneficial effects. However, poor
bioavailability and less water solubility render it unsuitable as an anti-cancer drug. Herein …

Targeting drug chemo-resistance in cancer using natural products

WH Talib, AR Alsayed, M Barakat, MI Abu-Taha… - Biomedicines, 2021 - mdpi.com
Cancer is one of the leading causes of death globally. The development of drug resistance
is the main contributor to cancer-related mortality. Cancer cells exploit multiple mechanisms …

Matrine: a promising natural product with various pharmacological activities

H Zhang, L Chen, X Sun, Q Yang, L Wan… - Frontiers in …, 2020 - frontiersin.org
Matrine is an alkaloid isolated from the traditional Chinese medicine Sophora flavescens
Aiton. At present, a large number of studies have proved that matrine has an anticancer …

[HTML][HTML] Artemisinin derivatives inhibit non-small cell lung cancer cells through induction of ROS-dependent apoptosis/ferroptosis

Q Zhang, H Yi, H Yao, L Lu, G He, M Wu… - Journal of …, 2021 - ncbi.nlm.nih.gov
Non-small cell lung cancer (NSCLC) is one of the major cancer-related causes of morbidity
and mortality worldwide. Despite the progress in lung cancer treatment, there is still an …

Current scenario of indole derivatives with potential anti-drug-resistant cancer activity

Y Jia, X Wen, Y Gong, X Wang - European Journal of Medicinal Chemistry, 2020 - Elsevier
Cancer chemotherapy is frequently hampered by drug resistance, so the resistance to
anticancer agents represents one of the major obstacles for the effective cancer treatment …

Tetrandrine: a review of its anticancer potentials, clinical settings, pharmacokinetics and drug delivery systems

F Luan, X He, N Zeng - Journal of Pharmacy and Pharmacology, 2020 - academic.oup.com
Objectives Tetrandrine, a natural bisbenzylisoquinoline alkaloid, possesses promising
anticancer activities on diverse tumours. This review provides systematically organized …