The prevalence of the metabolic syndrome, a cluster of cardiovascular risk factors
associated with obesity and insulin resistance, is dramatically increasing in Western and …

From a biological point of view, aging can be considered a progressive inability of an
organism to react to stress, maintain homeostasis, and survive unfavourable changes during …

Aging is associated with immunosenescence and accompanied by a chronic inflammatory
state which contributes to metabolic syndrome, diabetes and their cardiovascular …

Human aging is currently defined as a physiological decline of biological functions in the
body with a continual adaptation to internal and external damaging. The endocrine system …

This study indicates that glycosylation of immunoglobulin G, the most abundant antibody in
human blood, may convey useful information with regard to inflammation and metabolic …

By studying the loci that contribute to human longevity, we aim to identify mechanisms that
contribute to healthy aging. To identify such loci, we performed a genome‐wide association …

Middle‐aged offspring of nonagenarians, as compared to their spouses (controls), show a
favorable lipid metabolism marked by larger LDL particle size in men and lower total …

Conditions related to body composition and aging, such as osteopenic obesity,
sarcopenia/sarcopenic obesity, and the newly termed osteosarcopenic obesity (triad of bone …

There is now an impressive body of literature implicating insulin and insulin signaling in
successful aging and longevity. New information from in vivo and in vitro studies concerning …

Summary mTOR signalling is implicated in the development of disease and in lifespan
extension in model organisms. This pathway has been associated with human diseases …