Defining physiological normoxia for improved translation of cell physiology to animal models and humans
TP Keeley, GE Mann - Physiological reviews, 2019 - journals.physiology.org
The extensive oxygen gradient between the air we breathe (Po2~ 21 kPa) and its ultimate
distribution within mitochondria (as low as~ 0.5–1 kPa) is testament to the efforts expended …
distribution within mitochondria (as low as~ 0.5–1 kPa) is testament to the efforts expended …
Macrovasculature and microvasculature at the crossroads between type 2 diabetes mellitus and hypertension
Climie et al Macrovasculature and Microvasculature in HTN and T2D 1139 million global
disability-adjusted life years, an increase of 11.7% from 2005. 9 Because hypertension …
disability-adjusted life years, an increase of 11.7% from 2005. 9 Because hypertension …
[HTML][HTML] Stem cells differentiation into insulin-producing cells (IPCs): recent advances and current challenges
IBB Silva, CH Kimura, VP Colantoni… - Stem cell research & …, 2022 - Springer
Type 1 diabetes mellitus (T1D) is a chronic disease characterized by an autoimmune
destruction of insulin-producing β-pancreatic cells. Although many advances have been …
destruction of insulin-producing β-pancreatic cells. Although many advances have been …
[HTML][HTML] Partners in crime: beta-cells and autoimmune responses complicit in type 1 diabetes pathogenesis
E Toren, KLS Burnette, RR Banerjee… - Frontiers in …, 2021 - frontiersin.org
Type 1 diabetes (T1D) is an autoimmune disease characterized by autoreactive T cell-
mediated destruction of insulin-producing pancreatic beta-cells. Loss of beta-cells leads to …
mediated destruction of insulin-producing pancreatic beta-cells. Loss of beta-cells leads to …
[HTML][HTML] The pericyte of the pancreatic islet regulates capillary diameter and local blood flow
Efficient insulin secretion requires a well-functioning pancreatic islet microvasculature. The
dense network of islet capillaries includes the islet pericyte, a cell that has barely been …
dense network of islet capillaries includes the islet pericyte, a cell that has barely been …
[HTML][HTML] A critical role of the mechanosensor PIEZO1 in glucose-induced insulin secretion in pancreatic β-cells
Y Ye, M Barghouth, H Dou, C Luan, Y Wang… - Nature …, 2022 - nature.com
Glucose-induced insulin secretion depends on β-cell electrical activity. Inhibition of ATP-
regulated potassium (KATP) channels is a key event in this process. However, KATP …
regulated potassium (KATP) channels is a key event in this process. However, KATP …
In vivo–mimicking microfluidic perfusion culture of pancreatic islet spheroids
Native pancreatic islets interact with neighboring cells by establishing three-dimensional
(3D) structures, and are surrounded by perfusion at an interstitial flow level. However, flow …
(3D) structures, and are surrounded by perfusion at an interstitial flow level. However, flow …
Synchronized stimulation and continuous insulin sensing in a microfluidic human Islet on a Chip designed for scalable manufacturing
Pancreatic β cell function is compromised in diabetes and is typically assessed by
measuring insulin secretion during glucose stimulation. Traditionally, measurement of …
measuring insulin secretion during glucose stimulation. Traditionally, measurement of …
The role of the islet niche on beta cell structure and function
The islets of Langerhans or pancreatic islets are pivotal in the control of blood glucose and
are complex microorgans embedded within the larger volume of the exocrine pancreas …
are complex microorgans embedded within the larger volume of the exocrine pancreas …
[HTML][HTML] Conflicting views about interactions between pancreatic α-cells and β-cells
GC Weir, S Bonner-Weir - Diabetes, 2023 - Am Diabetes Assoc
In type 1 diabetes, the reduced glucagon response to insulin-induced hypoglycemia has
been used to argue that β-cell secretion of insulin is required for the full glucagon …
been used to argue that β-cell secretion of insulin is required for the full glucagon …