Fibroblasts synthesize the extracellular matrix of connective tissue and play an essential role
in maintaining the structural integrity of most tissues. Researchers have long suspected that …

The discovery of somatic cell nuclear transfer proved that somatic cells can carry the same
genetic code as the zygote, and that activating parts of this code are sufficient to reprogram …

Of all biologic matrices, decellularized extracellular matrix (dECM) has emerged as a
promising tool used either alone or when combined with other biologics in the fields of tissue …

Biologic scaffolds composed of extracellular matrix (ECM) are widely used in both preclinical
animal studies and in many clinical applications to repair and reconstruct tissues. Recently …

Bone tissue is a highly vascularized tissue and concomitant development of the vascular
system and mineralized matrix requires a synergistic interaction between osteogenesis and …

Biologic scaffold materials composed of extracellular matrix (ECM) are typically derived by
processes that involve decellularization of tissues or organs. Preservation of the complex …

Approximately 100,000 individuals in the United States currently await kidney
transplantation, and 400,000 individuals live with end-stage kidney disease requiring …

Biologic scaffold materials composed of allogeneic or xenogeneic extracellular matrix (ECM)
are commonly used for the repair and remodeling of injured tissue. The clinical outcomes …

End-stage organ failure is a key challenge for the medical community because of the ageing
population and the severe shortage of suitable donor organs available. Equally, injuries to …

The extracellular matrix is produced by the resident cells in tissues and organs, and
secreted into the surrounding medium to provide biophysical and biochemical support to the …