Discarded human kidneys as a source of ECM scaffold for kidney regeneration technologies

G Orlando, C Booth, Z Wang, G Totonelli, CL Ross… - Biomaterials, 2013 - Elsevier
In the United States, more than 2600 kidneys are discarded annually, from the total number
of kidneys procured for transplant. We hypothesized that this organ pool may be used as a …

Adipose-derived stromal cells mediate in vivo adipogenesis, angiogenesis and inflammation in decellularized adipose tissue bioscaffolds

TTY Han, S Toutounji, BG Amsden, LE Flynn - Biomaterials, 2015 - Elsevier
Decellularized adipose tissue (DAT) has shown promise as an adipogenic bioscaffold for
soft tissue augmentation and reconstruction. The objective of the current study was to …

Stem cells: a potential treatment option for kidney diseases

D Liu, F Cheng, S Pan, Z Liu - Stem cell research & therapy, 2020 - Springer
The prevalence of kidney diseases is emerging as a public health problem. Stem cells
(SCs), currently considered as a promising tool for therapeutic application, have aroused …

Porcine pancreas extracellular matrix as a platform for endocrine pancreas bioengineering

SH Mirmalek-Sani, G Orlando, JP McQuilling, R Pareta… - Biomaterials, 2013 - Elsevier
Emergent technologies of regenerative medicine have the potential to overcome the
limitations of organ transplantation by supplying tissues and organs bioengineered in the …

Full-thickness skin wound healing using human placenta-derived extracellular matrix containing bioactive molecules

JS Choi, JD Kim, HS Yoon, YW Cho - Tissue Engineering Part A, 2013 - liebertpub.com
The human placenta, a complex organ, which facilitates exchange between the fetus and
the mother, contains abundant extracellular matrix (ECM) components and well-preserved …

Comparison of methods for whole-organ decellularization in tissue engineering of bioartificial organs

M He, A Callanan - Tissue Engineering Part B: Reviews, 2013 - liebertpub.com
Organ transplantation is now a well-established procedure for the treatment of end-stage
organ failure due to various causes, but is a victim of its own success in that there is a …

Regenerative medicine and organ transplantation: past, present, and future

G Orlando, KJ Wood, RJ Stratta, JJ Yoo, A Atala… - …, 2011 - journals.lww.com
This overview traces the history of regenerative medicine pertinent to organ transplantation,
illustrates potential clinical applications reported to date, and highlights progress achieved …

A review of decellurization methods caused by an urgent need for quality control of cell‐free extracellular matrix'scaffolds and their role in regenerative medicine

M Kawecki, W Łabuś, A Klama‐Baryla… - … Research Part B …, 2018 - Wiley Online Library
The natural extracellular matrix (ECM), thanks to its specific properties (eg, collagenous
lattice, a reservoir of growth factors, ECM‐cell anchoring areas, an optimal pH and CO2) …

Biologic scaffolds

A Costa, JD Naranjo… - Cold Spring …, 2017 - perspectivesinmedicine.cshlp.org
Biologic scaffold materials composed of allogeneic or xenogeneic extracellular matrix are
commonly used for the repair and functional reconstruction of injured and missing tissues …

Feasibility of an implantable bioreactor for renal cell therapy using silicon nanopore membranes

EJ Kim, C Chen, R Gologorsky, A Santandreu… - Nature …, 2023 - nature.com
The definitive treatment for end-stage renal disease is kidney transplantation, which remains
limited by organ availability and post-transplant complications. Alternatively, an implantable …