Calcitonin gene-related peptide (CGRP) is a neuropeptide with diverse physiological
functions. Its two isoforms (α and β) are widely expressed throughout the body in sensory …

Recent studies by us and others have shown that enhancer of zeste homolog-2 (EZH2), a
histone methyltransferase, in glial cells regulates the genesis of neuropathic pain by …

This study examined the effects of turmeric bioactive compounds, curcumin C3
complex®(CUR) and bisdemethoxycurcumin (BDMC), on mechanical hypersensitivity and …

Using the structure of gliotoxin as a starting point, we have prepared two different
chemotypes with selective affinity to the kappa opioid receptor (KOR). Using medicinal …

Mental disorders such as anxiety and depression induced by chronic pain are common in
clinical practice, and there are significant sex differences in their epidemiology. However …

Neuropathic pain is a common health problem resulting in exacerbated response to noxious
and non noxious stimuli, as well as impaired emotional and cognitive responses …

The introduction of sex-as-a-biological-variable policies at funding agencies around the
world has led to an explosion of very recent observations of sex differences in the biology …

Pain is a multifaceted process that encompasses unpleasant sensory and emotional
experiences. The essence of the pain process is aversion, or perceived negative emotion …

Pain disrupts sleep, and sleep deprivation or interference can alter pain perception in
animals and humans, for example by increasing sensitivity to pain. However, the mechanism …

Introduction: Pain is a clinically relevant health care issue with limited therapeutic options,
creating the need for new and improved analgesic strategies. The amygdala is a limbic brain …