Autoimmune thyroid diseases (AITD) are common autoimmune diseases, affecting up to 5%
of the general population. Thyroid-directed autoimmunity is manifested in two classical …

Autoimmune diseases are characterized by dysfunctional immune systems that
misrecognize self as non‐self and cause tissue destruction. Several cell types have been …

Previous studies have attempted to define human leukocyte antigen (HLA) class II
supertypes, analogous to the case for class I, on the basis of shared peptide-binding motifs …

Human leukocyte antigen (HLA) class II antigen presentation is key for controlling and
triggering T cell immune responses. HLA-DQ molecules, which are believed to play a major …

Hypocretin-1 (orexin-A) was administered to sleep-deprived (30–36 h) rhesus monkeys
immediately preceding testing on a multi-image delayed match-to-sample (DMS) short-term …

A peptide derived from the insulin B chain contains a major epitope for diabetogenic CD4+ T
cells in the NOD mouse model of type 1 diabetes (T1D). This peptide can fill the binding …

This unit describes a technique for the direct and quantitative measurement of the capacity
of peptide ligands to bind Class I and Class II MHC molecules. The binding of a peptide of …

The allelic and haplotypic diversity of the HLA‐A, HLA‐B, and HLA‐C loci was investigated
in 852 subjects from five sub‐Saharan populations from Kenya (Nandi and Luo), Mali …

In antigen‐presenting cells (APCs), loading of major histocompatibility complex class II
(MHC II) molecules with peptides is regulated by invariant chain (Ii), which blocks MHC II …

The 8q24 locus, which contains the thyroglobulin (Tg) gene, was previously shown to be
strongly linked with autoimmune thyroid disease (AITD). We sequenced all 48 exons of the …