[HTML][HTML] Melatonin synthesis and function: evolutionary history in animals and plants

D Zhao, Y Yu, Z Zhao, R Sharma… - Frontiers in …, 2019 - frontiersin.org
Melatonin is an ancient molecule that can be traced back to the origin of life. Melatonin's
initial function was likely that as a free radical scavenger. Melatonin presumably evolved in …

Melatonin's impact on antioxidative and anti-inflammatory reprogramming in homeostasis and disease

DM Chitimus, MR Popescu, SE Voiculescu… - Biomolecules, 2020 - mdpi.com
There is a growing consensus that the antioxidant and anti-inflammatory properties of
melatonin are of great importance in preserving the body functions and homeostasis, with …

Oxidative stress and inflammation in COVID-19-associated sepsis: the potential role of anti-oxidant therapy in avoiding disease progression

J Beltrán-García, R Osca-Verdegal, FV Pallardó… - Antioxidants, 2020 - mdpi.com
Since the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak
emerged, countless efforts are being made worldwide to understand the molecular …

Pharmaceuticals targeting signaling pathways of endometriosis as potential new medical treatment: A review

SW Hung, R Zhang, Z Tan, JPW Chung… - Medicinal research …, 2021 - Wiley Online Library
Endometriosis (EM) is defined as endometrial tissues found outside the uterus. Growth and
development of endometriotic cells in ectopic sites can be promoted via multiple pathways …

Melatonin function and crosstalk with other phytohormones under normal and stressful conditions

M Khan, S Ali, H Manghwar, S Saqib, F Ullah, A Ayaz… - Genes, 2022 - mdpi.com
Melatonin was discovered in plants in the late nineties, but its role, signaling, and crosstalk
with other phytohormones remain unknown. Research on melatonin in plants has risen …

Melatonin and its protective role against biotic stress impacts on plants

M Moustafa-Farag, A Almoneafy, A Mahmoud… - Biomolecules, 2019 - mdpi.com
Biotic stress causes immense damage to agricultural products worldwide and raises the risk
of hunger in many areas. Plants themselves tolerate biotic stresses via several pathways …

Prophylactic melatonin for delirium in intensive care (Pro-MEDIC): a randomized controlled trial

B Wibrow, FE Martinez, E Myers, A Chapman… - Intensive Care …, 2022 - Springer
Purpose Delirium is common in the critically ill, highly distressing to patients and families
and associated with increased morbidity and mortality. Results of studies on preventative …

A critical review on recent trends on pharmacological applications of pyrazolone endowed derivatives

G Mustafa, M Zia-ur-Rehman, SH Sumrra… - Journal of Molecular …, 2022 - Elsevier
Pyrazolone is a well-known influential synthon for the synthesis of many molecules which
hold remarkable potential in the advancement of functional materials, coordination …

Efficacy and safety of anti-inflammatory agents in treatment of psychotic disorders–A comprehensive systematic review and meta-analysis

R Jeppesen, RHB Christensen, EMJ Pedersen… - Brain, behavior, and …, 2020 - Elsevier
Objective Antipsychotic effects of immunomodulating drugs have been suggested; however,
a thorough, comprehensive meta-analysis on the effect and safety of anti-inflammatory add …

Therapeutic potential of melatonin related to its role as an autophagy regulator: A review

JA Boga, B Caballero, Y Potes… - Journal of pineal …, 2019 - Wiley Online Library
There are several pathologies, syndromes, and physiological processes in which autophagy
is involved. This process of self‐digestion that cells trigger as a survival mechanism is …