Current therapies for multiple sclerosis (MS) reduce both relapses and relapse-associated
worsening of disability, which is assumed to be mainly associated with transient infiltration of …

Epidemiology and Pathophysiology of Multiple Sclerosis : CONTINUUM: Lifelong Learning in
Neurology Account Register Activate Subscription Help Subscribe American Academy of …

Microglia are implicated in all stages of multiple sclerosis (MS). Microglia alterations are
detected by positron emission tomography in people living with MS prior to the formation of …

Multiple sclerosis (MS) is an incurable autoimmune disease and is currently treated by
systemic immunosuppressants with off-target side effects. Although aberrant myeloid …

Macrophages are innate immune cells in the organism and can be found in almost tissues
and organs. They are highly plastic and heterogeneous cells and can participate in the …

This article recapitulates the evidence on the role of mammalian targets of rapamycin
(mTOR) complex pathways in multiple sclerosis (MS). Key biological processes that intersect …

Neurodegeneration and its loss of cognitive function is associated with inflammation and an
accumulation of lipids. In the periphery, cholesterol's uptake drives a major component of …

While most research and treatments for multiple sclerosis (MS) focus on autoimmune
reactions causing demyelination, it is possible that neurodegeneration precedes the …

Background Microglia regulate the response to injury and disease in the brain and spinal
cord. In white matter diseases microglia may cause demyelination. However, how microglia …

Bioactive metabolites isolated from myriad living organisms, particularly medicinal plants,
can synergize the therapeutic activities of conventional drugs. Catechin is a flavan-3-ol …